Insights into the Reaction of Protein-tyrosine Phosphatase 1B: CRYSTAL STRUCTURES FOR TRANSITION STATE ANALOGS OF BOTH CATALYTIC STEPS
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Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas’ diseaseNew Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate ScreeningThe molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1BSHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound statesMolecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsNitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition stateThe metal face of protein tyrosine phosphatase 1BVoltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function researchConservative tryptophan mutants of the protein tyrosine phosphatase YopH exhibit impaired WPD-loop function and crystallize with divanadate esters in their active sitesChemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptidesA HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities.Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.Using NMR spectroscopy to elucidate the role of molecular motions in enzyme functionA conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation.New functional aspects of the atypical protein tyrosine phosphatase VHZ.Kinetic isotope effects in the characterization of catalysis by protein tyrosine phosphatases.Recent advances in the development of protein tyrosine phosphatase 1B inhibitors for Type 2 diabetes.Catalytic scaffolds for phosphoryl group transfer.Chemical Approaches to Studying Labile Amino Acid Phosphorylation.Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N 1-phosphotryptophan and S-phosphocysteine.The interactions of metal cations and oxyanions with protein tyrosine phosphatase 1BConformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases.Metavanadate at the active site of the phosphatase VHZBis(acetylacetonato)-oxovanadium(iv), bis(maltolato)-oxovanadium(iv) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt.Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase β activity.Effects of protonation state of Asp181 and position of active site water molecules on the conformation of PTP1B.Inhibition of ecto-phosphatase activity in conidia reduces adhesion and virulence of Metarhizium anisopliae on the host insect Dysdercus peruvianus.Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders.Prediction of the interaction of metallic moieties with proteins: An update for protein-ligand docking techniques.Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid.Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases.Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice.Zinc ions modulate protein tyrosine phosphatase 1B activity.Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches.Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
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P2860
Insights into the Reaction of Protein-tyrosine Phosphatase 1B: CRYSTAL STRUCTURES FOR TRANSITION STATE ANALOGS OF BOTH CATALYTIC STEPS
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2010 nî lūn-bûn
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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2010 թվականի մայիսին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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P2860
P921
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Insights into the Reaction of ...... NALOGS OF BOTH CATALYTIC STEPS
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P2093
Alvan C Hengge
Tiago A S Brandão
P2860
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P3181
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10.1074/JBC.M109.066951
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P50
P577
2010-05-21T00:00:00Z