Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study
about
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actionsStructure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactionsAlanine scanning of a putative receptor binding surface of insulin-like growth factor-IMolecular signaling involving intrinsically disordered proteins in prostate cancerAn automatic refolding apparatus for preparative-scale protein productionSolution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-IThe interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading EnzymeKnowledge-Based Protein ModelingBinding sites and binding properties of binary and ternary complexes of insulin-like growth factor-II (IGF-II), IGF-binding protein-3, and acid-labile subunitThe insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysisDesign and characterisation of long-R3-insulin-like growth factor-I muteins which show resistance to pepsin digestion.Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis.Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1).Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.Unbound (bioavailable) IGF1 enhances somatic growth.What's new in the IGF-binding proteins?IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718.A peptide model of insulin folding intermediate with one disulfideCharacterization of ligand binding of a soluble human insulin-like growth factor I receptor variant suggests a ligand-induced conformational change.Insulin: a small protein with a long journey.Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation.Theoretical and computational studies of peptides and receptors of the insulin family.Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins.Binding affinities of insulin-like growth factor-I (IGF-I) fusion proteins to IGF binding protein 1 and IGF-I receptor are not correlated with mitogenic activity.Oxidative folding of cystine-rich peptides vs regioselective cysteine pairing strategies.Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding.Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.Peptide models of four possible insulin folding intermediates with two disulfides.Mutations in the B-domain of insulin-like growth factor-I influence the oxidative folding to yield products with modified biological propertiesContribution of residues A54 and L55 of the human insulin-like growth factor-II (IGF-II) A domain to Type 2 IGF receptor binding specificity.Transcriptional regulation and biological significance of the insulin like growth factor II gene.Three-dimensional solution structure of a disulfide bond isomer of the human insulin-like growth factor-I.The Insulin-like Growth Factor (IGF) Binding Site of Bovine Insulin-like Growth Factor Binding Protein-2 (bIGFBP-2) Probed by Iodination
P2860
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P2860
Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study
description
1991 nî lūn-bûn
@nan
1991 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Solution structure of human in ...... ained molecular dynamics study
@ast
Solution structure of human in ...... ained molecular dynamics study
@en
Solution structure of human in ...... ained molecular dynamics study
@nl
type
label
Solution structure of human in ...... ained molecular dynamics study
@ast
Solution structure of human in ...... ained molecular dynamics study
@en
Solution structure of human in ...... ained molecular dynamics study
@nl
prefLabel
Solution structure of human in ...... ained molecular dynamics study
@ast
Solution structure of human in ...... ained molecular dynamics study
@en
Solution structure of human in ...... ained molecular dynamics study
@nl
P2093
P3181
P356
P1433
P1476
Solution structure of human in ...... ained molecular dynamics study
@en
P2093
I D Campbell
T S Harvey
P304
P3181
P356
10.1021/BI00236A022
P407
P577
1991-06-04T00:00:00Z