Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis
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Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiencyA spring-loaded release mechanism regulates domain movement and catalysis in phosphoglycerate kinaseConformational dynamics in phosphoglycerate kinase, an open and shut case?Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMPInsulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuniNear attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrateTying down the arm in Bacillus dUTPase: structure and mechanismNucleotide promiscuity of 3-phosphoglycerate kinase is in focus: implications for the design of better anti-HIV analoguesMeasurement of the intrinsic variability within protein crystals: implications for sample-evaluation and data-collection strategiesα-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP HydrolysisAn allosteric signaling pathway of human 3-phosphoglycerate kinase from force distribution analysisA structural perspective of compensatory evolutionMechanisms of protein sequence divergence and incompatibility.OptZyme: computational enzyme redesign using transition state analoguesThe energy landscape of adenylate kinase during catalysis.Thioredoxin-dependent redox regulation of chloroplastic phosphoglycerate kinase from Chlamydomonas reinhardtii.Virtual Screening against Phosphoglycerate Kinase 1 in Quest of Novel Apoptosis Inhibitors.Protein Stability, Folding and Misfolding in Human PGK1 Deficiency.Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, 19 F NMR, and DFT Approaches.Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes.Metal Fluorides: Tools for Structural and Computational Analysis of Phosphoryl Transfer Enzymes.1H, 15N, 13C backbone resonance assignments of human phosphoglycerate kinase in a transition state analogue complex with ADP, 3-phosphoglycerate and magnesium trifluoride.Expression, purification, crystallization and preliminary X-ray diffraction studies of phosphoglycerate kinase from methicillin-resistant Staphylococcus aureus MRSA252.The catalytic mechanism of protein phosphatase 5 established by DFT calculations.Direct cryocooling of naked crystals: are cryoprotection agents always necessary?Theoretical studies of cyclic adenosine monophosphate dependent protein kinase: native enzyme and ground-state and transition-state analogues.MgF3- and AlF4- transition state analogue complexes of yeast phosphoglycerate kinase.Insights into human phosphoglycerate kinase 1 deficiency as a conformational disease from biochemical, biophysical, and in vitro expression analyses.Dissection of the difference between the group I metal ions in inhibiting GSK3β: a computational study.On the mechanism of phosphoenolpyruvate synthetase (PEPs) and its inhibition by sodium fluoride: potential magnesium and aluminum fluoride complexes of phosphoryl transfer.Polyphosphate-containing bisubstrate analogues as inhibitors of a bacterial cell wall thymidylyltransferase.Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.Synthesis, structure and reactivity of a terminal magnesium fluoride compound, [TpBut,Me]MgF: hydrogen bonding, halogen bonding and C-F bond formation.
P2860
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P2860
Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Transition state analogue stru ...... of charge balance in catalysis
@ast
Transition state analogue stru ...... of charge balance in catalysis
@en
Transition state analogue stru ...... of charge balance in catalysis
@nl
type
label
Transition state analogue stru ...... of charge balance in catalysis
@ast
Transition state analogue stru ...... of charge balance in catalysis
@en
Transition state analogue stru ...... of charge balance in catalysis
@nl
prefLabel
Transition state analogue stru ...... of charge balance in catalysis
@ast
Transition state analogue stru ...... of charge balance in catalysis
@en
Transition state analogue stru ...... of charge balance in catalysis
@nl
P2093
P356
P1476
Transition state analogue stru ...... of charge balance in catalysis
@en
P2093
Andrea M Hounslow
Andrea Varga
G Michael Blackburn
James P Marston
Jonathan P Waltho
Judit Szabó
Matthew J Cliff
Nicola J Baxter
P304
P356
10.1021/JA100974T
P407
P577
2010-05-12T00:00:00Z