Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6 - Test2 - elhamkhani - TriplyDB

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6

http://www.wikidata.org/entity/Q27661705

about

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition TYK2 kinase activity is required for functional type I interferon responses in vivo Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).High-precision isothermal titration calorimetry with automated peak-shape analysis.Adapter protein Shc regulates Janus kinase 3 phosphorylation Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes.EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer.Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3).Tofacitinib for the treatment of rheumatoid arthritis.Identification of molecular switch regulating interactions of Janus kinase 3 with cytoskeletal proteins.A displaced-solvent functional analysis of model hydrophobic enclosures.Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma The molecular basis of IL-10 function: from receptor structure to the onset of signaling.MoNetFamily: a web server to infer homologous modules and module-module interaction networks in vertebrates Establishing the role of tyrosine kinase 2 in cancer.Comparative analysis of the human and zebrafish kinomes: focus on the development of kinase inhibitors.Biology and significance of the JAK/STAT signalling pathways.The use of structural biology in Janus kinase targeted drug discovery.Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F.STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease.JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical.Approaches to efficiently estimate solvation and explicit water energetics in ligand binding: the use of WaterMap.Therapeutic potential of tyrosine kinase 2 in autoimmunity.Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials.Selective JAK inhibitors.Progress toward JAK1-selective inhibitors.Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation.Inhibitor-based affinity probes for the investigation of JAK signaling pathways.Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.Enhancing specificity in the Janus kinases: a study on the thienopyridine JAK2 selective mechanism combined molecular dynamics simulation.Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex.Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.Global connectivity of hub residues in Oncoprotein structures encodes genetic factors dictating personalized drug response to targeted Cancer therapy.

P2860

Q27670859-369A711A-C617-4130-9EC8-F6A8F1BED0C8 Q27673465-8B6D7E34-FE32-4637-BECF-8A91B50ECDBB Q27683852-2AF863DD-F78E-43D5-A7DB-F2C71AD8BF2F Q28728338-F8D341D4-3C68-4F76-AFB9-877181A92D6E Q30313903-AC06585E-BF18-4ED6-A32B-59922060C2AE Q30519497-F870EF0A-E4DD-4CCA-831A-392F2EE76E4E Q33718415-095E1AF0-4F3C-4852-820B-C34665516148 Q34022661-F2CA3633-116D-43C0-8F35-2870EDF56F43 Q34028255-0939F7AB-E633-4286-A7EF-9532884B6181 Q34163334-22C49713-53D9-4AF1-BF74-0AEA3788074D Q34244067-7D05226D-A108-46F6-A2CB-4DAD13E498B1 Q34270442-105C3542-F8C6-4B66-8557-EE60A9888149 Q34275878-C54B29FD-C066-42D3-8BE9-A1BA59B0D0A0 Q34301976-0708F585-3E8A-4D4B-8350-79243B46FE50 Q34377040-D4103010-7B23-40A7-BF73-60BB43873193 Q35228409-F8FA106B-BB05-47F8-A561-DA2EC2BB3837 Q35346411-21DE1DC4-7F63-4073-AF2F-C0A56BBC39C3 Q35810601-400AAA17-C0D9-4EDE-BD0D-94D033328C02 Q36088514-6AF0C8FD-2708-463C-8F8A-99316A6D5851 Q36643671-87398DB7-ED83-4DC5-AF66-7A43559B0E71 Q36710783-E6898E52-E5D3-463D-B4C0-E8D4FE231400 Q37146441-AD2DF7A0-E73B-4512-9AF0-22D8EB1C66F8 Q37206115-BC2CF362-48A5-4162-A228-26B391A09796 Q37293986-6A445491-D658-4189-90A8-DF15B8C93AC3 Q37718730-74D4C4E2-5BA2-4086-A297-F4DB245021C9 Q38065100-A2C2AFE1-B044-4D8E-BA14-74922AD8EC37 Q38071408-0BB4E92A-2150-4ACA-A394-AA12AF83322F Q38198086-F27928E2-A694-4523-9EA0-011E13E2C815 Q38250318-5C909242-3738-428B-9B36-C70BF3BD9A76 Q38261371-9C334BF0-DB6F-4998-A404-FC1D28D4F728 Q38357083-8DE3DC1D-F35D-497C-95BE-E9ABDEDC1F84 Q38655324-14107A6A-4F4E-454D-935C-D2CDFACE34AC Q38877092-75067A94-89D1-45E1-A5B6-675A6D4EAF3B Q38887338-4945DF44-3342-4CD7-A796-8E490B4E74B5 Q38924086-361B4FDD-43D0-4EE2-B05C-972AA87D2F58 Q39222478-3C346447-C4C8-476A-90AB-F5B4CD6F448E Q40188503-CBF02624-582C-40EE-8392-64F106443993 Q41792413-D5064807-3DEA-4472-86B3-DEFC383E75F7 Q41835379-2B7BF1FF-A126-4271-9394-24BF22DE897F Q42233673-1D218011-B73F-4457-889E-931CD8805649

P2860

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6

http://www.wikidata.org/entity/Q27661705

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@ast

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@en

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@nl

type

label

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@ast

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@en

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@nl

prefLabel

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@ast

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@en

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@nl

P1433

Q27661705-AD1D52B9-C333-495B-956F-F28B3CE09C25

P1476

Q27661705-FC60C539-FC33-4B88-9573-4D784855732F

P2093

Q27661705-10154FFF-4B88-4FFB-84B7-F283A1197593

Q27661705-139051F6-CBD0-4B2B-83FC-7952F0B1854C

Q27661705-17CBD241-3C8B-4709-A3B3-766553960E72

Q27661705-1EB6D81D-BFCC-4E4A-92A3-0417372F624B

Q27661705-5307D2B0-DF08-4939-97D4-7419B58AE6B4

Q27661705-55B9FD83-A806-4145-BA19-178CB19263CE

Q27661705-59108E68-9A9C-44CA-8825-3C8545E2473F

Q27661705-6B6828FA-D1D8-4D90-9557-97B369E90716

Q27661705-719777CF-D80D-4B7F-AC7F-F16E4EE46916

Q27661705-764972D3-F9FE-4963-BEFC-2DCFF867DD22

P304

Q27661705-53870F8F-52FD-4DF7-87FB-92E7A8771D17

P31

Q27661705-E25E1AB6-6EDB-4105-90A4-B3F399B3A467

P356

Q27661705-DAA82EBF-E53B-4C69-ABBE-748CDE1E29CF

P407

Q27661705-54543EDF-ECE5-4B2F-B4B5-B4BA38408EE7

P433

Q27661705-D269C99D-785D-4215-9289-282A73936D01

P478

Q27661705-842C18EF-8B8A-4C38-8350-68453C5F49D7

P577

Q27661705-B2119B86-7E87-48C6-907D-9A8746B53A62

P698

Q27661705-62409EF4-9501-487B-96EB-7D4E12D5DFEE

P356

J.JMB.2010.05.020

P1433

Journal of Molecular Biology

P1476

Structural and thermodynamic c ...... mplex with CP-690550 and CMP-6

@en

P2093

Akshay Patny

http://www.w3.org/2001/XMLSchema#string

Alfredo G Tomasselli

http://www.w3.org/2001/XMLSchema#string

Brian Korniski

http://www.w3.org/2001/XMLSchema#string

Cynthia D Sommers

http://www.w3.org/2001/XMLSchema#string

E J Jacobsen

http://www.w3.org/2001/XMLSchema#string

H David Fischer

http://www.w3.org/2001/XMLSchema#string

Horng-Chih Huang

http://www.w3.org/2001/XMLSchema#string

Iris K Leung

http://www.w3.org/2001/XMLSchema#string

Jacqueline E Day

http://www.w3.org/2001/XMLSchema#string

James R Kiefer

http://www.w3.org/2001/XMLSchema#string

P304

413-33

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.JMB.2010.05.020

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

400

http://www.w3.org/2001/XMLSchema#string

P577

2010-07-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20478313

http://www.w3.org/2001/XMLSchema#string