Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state

Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state

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http://www.wikidata.org/entity/Q27664133
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4JNK Signaling: Regulation and Functions Based on Complex Protein-Protein PartnershipsCrystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition stateInsights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinomeMAP kinase modules: the excursion model and the steps that count.Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies.Therapeutic modulation of prostate cancer metastasis.Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression.The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle.
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Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state

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http://www.wikidata.org/entity/Q27664133
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2010 nî lūn-bûn
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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@ast
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@en
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@nl
type
label
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@ast
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@en
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@nl
prefLabel
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@ast
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@en
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Crystal structures of MKK4 kin ...... duces an auto-inhibition state
@en
P2093
P304
P31
P356
10.1016/J.BBRC.2010.08.071
P407
P433
P478
P577
P698
P921