Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN - Test2 - elhamkhani - TriplyDB

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

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Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae A highly conserved mycobacterial cholesterol catabolic pathway Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE(CYP152L1) from theJeotgalicoccussp. 8456 Bacterium Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1 Crystal Structure of a Putative Cytochrome P450 Alkane Hydroxylase (CYP153D17) from Sphingomonas sp. PAMC 26605 and Its Conformational Substrate Binding Catabolism and biotechnological applications of cholesterol degrading bacteria.Characterization of Cupriavidus metallidurans CYP116B1--a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.Cholesterol ester oxidation by mycobacterial cytochrome P450.Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors.Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.Genome-Wide Transcriptome Profiling of Mycobacterium smegmatis MC² 155 Cultivated in Minimal Media Supplemented with Cholesterol, Androstenedione or Glycerol.Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage.Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets.Advances In Mycobacterium Tuberculosis Therapeutics Discovery Utlizing Structural Biology.Updating and curating metabolic pathways of TB.3-Ketosteroid 9α-hydroxylase enzymes: Rieske non-heme monooxygenases essential for bacterial steroid degradation.Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.Cholesterol metabolism: a potential therapeutic target in Mycobacteria.The Role of fadD19 and echA19 in Sterol Side Chain Degradation by Mycobacterium smegmatis.Comparative Study of GeneXpert MTB/RIF Assay and Multiplex PCR Assay for Direct Detection of Mycobacterium tuberculosis in Suspected Pulmonary Tuberculosis Patients.Deciphering the transcriptional regulation of cholesterol catabolic pathway in mycobacteria: identification of the inducer of KstR repressor.Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.A natural heme-signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω-hydroxylation.Functional characterization of three specific acyl-coenzyme A synthetases involved in anaerobic cholesterol degradation in Sterolibacterium denitrificans Chol1S.Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.Structure and function of the cytochrome P450 peroxygenase enzymes.Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

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P2860

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

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2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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Structural and Biochemical Cha ...... ACTIVITIES IN A HUMAN PATHOGEN

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Structural and Biochemical Cha ...... ACTIVITIES IN A HUMAN PATHOGEN

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Structural and Biochemical Cha ...... ACTIVITIES IN A HUMAN PATHOGEN

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Structural and Biochemical Cha ...... ACTIVITIES IN A HUMAN PATHOGEN

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Structural and Biochemical Cha ...... ACTIVITIES IN A HUMAN PATHOGEN

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JBC.M110.164293

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Journal of Biological Chemistry

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Structural and biochemical cha ...... activities in a human pathogen

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Colin Levy

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David Leys

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Stephen E J Rigby

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P2860

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one

Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids

The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection

Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis

PHENIX: a comprehensive Python-based system for macromolecular structure solution

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450

Characterization of Active Site Structure in CYP121: A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37Rv

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38270-38282

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10.1074/JBC.M110.164293

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49

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285

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Irina A Pikuleva

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2010-09-30T00:00:00Z

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20889498

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Mycobacterium tuberculosis

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2992261

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