Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases - Test2 - elhamkhani - TriplyDB

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

http://www.wikidata.org/entity/Q27666021

about

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry Human OGA binds substrates in a conserved peptide recognition groove A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum Chemical approaches to study O-GlcNAcylation.Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.O-GlcNAc and the cardiovascular system.Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology.Protein O-GlcNAcylation in diabetes and diabetic complications.Chemical tools to probe cellular O-GlcNAc signalling.Mechanism of Human Nucleocytoplasmic Hexosaminidase D.Molecular recognition: O-GlcNAc transfer: size matters.Protein-ligand interaction study of CpOGA in complex with GlcNAcstatin.Multivalency To Inhibit and Discriminate Hexosaminidases.Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human -GlcNAcase

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P2860

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

http://www.wikidata.org/entity/Q27666021

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Cell-Penetrant, Nanomolar O-Gl ...... inst Lysosomal Hexosaminidases

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Cell-Penetrant, Nanomolar O-Gl ...... inst Lysosomal Hexosaminidases

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Cell-Penetrant, Nanomolar O-Gl ...... inst Lysosomal Hexosaminidases

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Cell-Penetrant, Nanomolar O-Gl ...... inst Lysosomal Hexosaminidases

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Chemistry and Biology

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Cell-Penetrant, Nanomolar O-Gl ...... inst Lysosomal Hexosaminidases

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Daan M F van Aalten

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Helge C Dorfmueller

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Kevin D Read

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Xiaowei Zheng

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P2860

Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats

Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease

Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

GlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylation

Coot: model-building tools for molecular graphics

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