Mechanism for selectivity-inactivation coupling in KcsA potassium channels
about
Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeationA molecular switch driving inactivation in the cardiac K+ channel HERGStructural correlates of selectivity and inactivation in potassium channels.Potassium-selective block of barium permeation through single KcsA channelsThermodynamics of ion selectivity in the KcsA K+ channel.Origins of ion selectivity in potassium channels from the perspective of channel block.Perspectives on: ion selectivity: design principles for K+ selectivity in membrane transport.A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.Residues at the outer mouth of Kir1.1 determine K-dependent gating.Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains.Protonation state of E71 in KcsA and its role for channel collapse and inactivation.Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage displayRole of protein dynamics in ion selectivity and allosteric coupling in the NaK channel.Filter gate closure inhibits ion but not water transport through potassium channelsMulti-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channelConformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.Transmembrane allosteric coupling of the gates in a potassium channel.Dynamics transitions at the outer vestibule of the KcsA potassium channel during gating.K(+) and Na(+) conduction in selective and nonselective ion channels via molecular dynamics simulationsStructure of potassium channels.Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel.Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.Ion channels and ion selectivity.Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA.Pore size matters for potassium channel conductance.Single-step electrochemical functionalization of double-walled carbon nanotube (DWCNT) membranes and the demonstration of ionic rectification.Dynamic water patterns change the stability of the collapsed filter conformation of the KcsA K+ channel.Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel.Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation.Complex interactions among residues within pore region determine the K+ dependence of a KAT1-type potassium channel AmKAT1.Structural properties determining low K+ affinity of the selectivity filter in the TWIK1 K+ channel.Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.
P2860
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P2860
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
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2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
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2011年论文
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name
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@ast
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@en
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@nl
type
label
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@ast
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@en
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@nl
prefLabel
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@ast
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@en
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@nl
P2093
P2860
P3181
P356
P1476
Mechanism for selectivity-inactivation coupling in KcsA potassium channels
@en
P2093
Ameer N Thompson
Colin G Nichols
Crina M Nimigean
Jason G McCoy
Wayland W L Cheng
P2860
P304
P3181
P356
10.1073/PNAS.1014186108
P407
P577
2011-03-29T00:00:00Z