Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex
about
Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathwayStructure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteinsTail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologueCrystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4Structure of the Sgt2 dimerization domain complexed with the Get5 UBL domain involved in the targeting of tail-anchored membrane proteins to the endoplasmic reticulumStructural and functional characterization of ybr137wp implicates its involvement in the targeting of tail-anchored proteins to membranes.The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions.In search of tail-anchored protein machinery in plants: reevaluating the role of arsenite transporters.Design, purification and characterization of a soluble variant of the integral membrane protein MotB for structural studiesDifferential gradients of interaction affinities drive efficient targeting and recycling in the GET pathwayThe association of BAG6 with SGTA and tail-anchored proteinsWRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.Epstein-Barr viral BNLF2a protein hijacks the tail-anchored protein insertion machinery to block antigen processing by the transport complex TAP.Nucleotide-dependent mechanism of Get3 as elucidated from free energy calculations.The complex process of GETting tail-anchored membrane proteins to the ER.TRC40 can deliver short secretory proteins to the Sec61 translocon.Mechanism of Assembly of a Substrate Transfer Complex during Tail-anchored Protein Targeting.Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked.Precise timing of ATPase activation drives targeting of tail-anchored proteins.Mutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function.Tail-anchored membrane protein insertion into the endoplasmic reticulum.Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance.A portrait of the GET pathway as a surprisingly complicated young man.Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.All roads lead to Rome (but some may be harder to travel): SRP-independent translocation into the endoplasmic reticulum.Transcriptional regulation of secretory capacity by bZip transcription factors.The emerging role of calcium-modulating cyclophilin ligand in posttranslational insertion of tail-anchored proteins into the endoplasmic reticulum membrane.Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR.ATPase and GTPase Tangos Drive Intracellular Protein Transport.Validation and correction of Zn-CysxHisy complexes.The mechanism of tail-anchored protein insertion into the ER membrane.Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.Multiple selection filters ensure accurate tail-anchored membrane protein targeting.Hydrophobic handoff for direct delivery of peroxisome tail-anchored proteins.Mechanistic basis for a molecular triage reactionTail-Anchored Protein Insertion by a Single Get1/2 Heterodimer.A protean clamp guides membrane targeting of tail-anchored proteins.
P2860
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P2860
Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
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2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@ast
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@en
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@nl
type
label
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@ast
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@en
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@nl
prefLabel
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@ast
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@en
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Structural Basis for Tail-Anch ...... s by the Get3-Receptor Complex
@en
P2093
Christopher Hein
Daniel Schwarz
Jörg Bomke
Simon Reitz
Susanne Stefer
Vladimir Denic
Yin-Yuin Pang
P2860
P304
P3181
P356
10.1126/SCIENCE.1207125
P407
P577
2011-08-05T00:00:00Z