A TOG: -tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase - Test2 - elhamkhani - TriplyDB

A TOG: -tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

A TOG: -tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

http://www.wikidata.org/entity/Q27671583

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A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation CLASP2 Has Two Distinct TOG Domains That Contribute Differently to Microtubule Dynamics Ahead of the Curve: New Insights into Microtubule Dynamics MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics Statistical mechanics provides novel insights into microtubule stability and mechanism of shrinkage Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism.Molecular mechanism of action of microtubule-stabilizing anticancer agents High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array Biochemical and Structural Insights into Microtubule Perturbation by CopN from Chlamydia pneumoniae A tethered delivery mechanism explains the catalytic action of a microtubule polymerase Structural basis of microtubule stabilization by laulimalide and peloruside A Antivascular and antitumor properties of the tubulin-binding chalcone TUB091 Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels Crescerin uses a TOG domain array to regulate microtubules in the primary cilium Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe.Cytoskeleton-associated protein 5 and clathrin heavy chain binding regulates spindle assembly in mouse oocytes.A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules.Stu2, the budding yeast XMAP215/Dis1 homolog, promotes assembly of yeast microtubules by increasing growth rate and decreasing catastrophe frequency The contribution of αβ-tubulin curvature to microtubule dynamics.Drosophila melanogaster mini spindles TOG3 utilizes unique structural elements to promote domain stability and maintain a TOG1- and TOG2-like tubulin-binding surface Microtubules in plants Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity.Emergent Properties of the Metaphase Spindle.Structures of potent anticancer compounds bound to tubulin Encoding the microtubule structure: Allosteric interactions between the microtubule +TIP complex master regulators and TOG-domain proteins.Theoretical and experimental study of polycyclic aromatic compounds as β-tubulin inhibitors.Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips.A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics Eribulin targets a ch-TOG-dependent directed migration of cancer cells Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.Visualizing microtubule structural transitions and interactions with associated proteins.The growth speed of microtubules with XMAP215-coated beads coupled to their ends is increased by tensile force.Molecular evolution and functional divergence of tubulin superfamily in the fungal tree of life Building complexity: insights into self-organized assembly of microtubule-based architectures Dynamic instability 30 years later: complexities in microtubule growth and catastrophe.

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A TOG: -tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

http://www.wikidata.org/entity/Q27671583

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2012 nî lūn-bûn

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2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

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2012年の論文

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A TOG: -tubulin Complex Struc ...... s for a Microtubule Polymerase

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A TOG: -tubulin Complex Struc ...... s for a Microtubule Polymerase

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A TOG: -tubulin Complex Struc ...... s for a Microtubule Polymerase

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A TOG: -tubulin Complex Struc ...... s for a Microtubule Polymerase

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Luke M Rice

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Patrick Huddleston

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Pelin Ayaz

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Xuecheng Ye

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P2860

Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Refined structure of alpha beta-tubulin at 3.5 A resolution

Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding

The lattice as allosteric effector: Structural studies of - and -tubulin clarify the role of GTP in microtubule assembly

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

Features and development of Coot

Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast

Microtubule polymerization dynamics

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857-60

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10.1126/SCIENCE.1221698

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Chad A Brautigam

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22904013

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