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Development of new estrogen receptor-targeting therapeutic agents for tamoxifen-resistant breast cancerThe structural biology of oestrogen metabolismStructural diversity of eukaryotic membrane cytochrome p450sIn vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17β-dihydroexemestaneDesign and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activitiesRecent Structural Insights into Cytochrome P450 Function.Mechanism of inhibition of estrogen biosynthesis by azole fungicides.3D QSAR studies, pharmacophore modeling and virtual screening on a series of steroidal aromatase inhibitors.Evidence for an elevated aspartate pK(a) in the active site of human aromataseDynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopyProbing the origins of aromatase inhibitory activity of disubstituted coumarins via QSAR and molecular dockingTwo aromatase inhibitors inhibit the ability of a third to promote mating in male ratsRecent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamateMolecular simulations of aromatase reveal new insights into the mechanism of ligand binding.Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes.Binding mode of triazole derivatives as aromatase inhibitors based on docking, protein ligand interaction fingerprinting, and molecular dynamics simulation studies.Computational methods for the design of potent aromatase inhibitors.Human aromatase: perspectives in biochemistry and biotechnology.The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications.A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β.Correction: Xie, H.; et al. 3D QSAR studies, pharmacophore modeling and virtual screening on a series of steroidal aromatase inhibitors. Int. J. Mol. Sci. 2014, 15, 20927-20947.Exploring the chemical space of aromatase inhibitors.Working at the membrane interface: Ligand-induced changes in dynamic conformation and oligomeric structure in human aromatase.3D-QSAR study of steroidal and azaheterocyclic human aromatase inhibitors using quantitative profile of protein-ligand interactions.Large-scale computational drug repositioning to find treatments for rare diseases.Testosterone complex and non-steroidal ligands of human aromatase.Design, synthesis, in silico, and in vitro evaluation of novel pyrimidine phosphonates with cytotoxicity against breast cancer cells
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Novel Aromatase Inhibitors by Structure-Guided Design
@ast
Novel Aromatase Inhibitors by Structure-Guided Design
@en
Novel Aromatase Inhibitors by Structure-Guided Design
@nl
type
label
Novel Aromatase Inhibitors by Structure-Guided Design
@ast
Novel Aromatase Inhibitors by Structure-Guided Design
@en
Novel Aromatase Inhibitors by Structure-Guided Design
@nl
prefLabel
Novel Aromatase Inhibitors by Structure-Guided Design
@ast
Novel Aromatase Inhibitors by Structure-Guided Design
@en
Novel Aromatase Inhibitors by Structure-Guided Design
@nl
P2093
P2860
P356
P1476
Novel Aromatase Inhibitors by Structure-Guided Design
@en
P2093
Chinaza Egbuta
Damien Valette
Huw M L Davies
Jennifer Griswold
Jessica Lo
Susan Hubbell
Wenhua Jiang
P2860
P304
P356
10.1021/JM300930N
P407
P577
2012-10-11T00:00:00Z