Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease - Test2 - elhamkhani - TriplyDB

Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

http://www.wikidata.org/entity/Q27674859

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Mitochondrial DNA damage and its consequences for mitochondrial gene expression Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2 Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity Nonhomologous end joining: a good solution for bad ends Impact of DNA3'pp5'G capping on repair reactions at DNA 3' ends.Neurological disorders associated with DNA strand-break processing enzymes.Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Recognition and repair of chemically heterogeneous structures at DNA ends Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.DNA end processing by polynucleotide kinase/phosphatase.DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition.Ribonucleotide triggered DNA damage and RNA-DNA damage responses Characterization of 3'-Phosphate RNA Ligase Paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus Highlights DNA and RNA 5'-Phosphate Capping Activity of RtcB3.APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress.Repair of double-strand breaks by end joining.The spatial organization of non-homologous end joining: from bridging to end joining.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Characterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domain.The DNA Repair Repertoire of Mycobacterium smegmatis FenA Includes the Incision of DNA 5' Flaps and the Removal of 5' Adenylylated Products of Aborted Nick Ligation.Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar.

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

http://www.wikidata.org/entity/Q27674859

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

@zh-tw

2011年论文

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name

Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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Nature Structural & Molecular Biology

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Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

@en

P2093

C Denise Appel

http://www.w3.org/2001/XMLSchema#string

Ivan Ahel

http://www.w3.org/2001/XMLSchema#string

Jessica S Williams

http://www.w3.org/2001/XMLSchema#string

Joe Krahn

http://www.w3.org/2001/XMLSchema#string

Patrick D Robertson

http://www.w3.org/2001/XMLSchema#string

Percy Tumbale

http://www.w3.org/2001/XMLSchema#string

R Scott Williams

http://www.w3.org/2001/XMLSchema#string

Rolf Kraehenbuehl

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P2860

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

Actions of aprataxin in multiple DNA repair pathways

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends

Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities

Structure-based analysis of catalysis and substrate definition in the HIT protein family

MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family

Eukaryotic DNA ligases: structural and functional insights

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases

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1189-95

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10.1038/NSMB.2146

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11

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18

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1010803594

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21984210

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neurodegeneration

single-strand break-containing DNA binding

structural biology

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3210380

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