3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses
about
Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host CellsReplication and Inhibitors of Enteroviruses and ParechovirusesFrom SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug designGenetic changes found in a distinct clade of Enterovirus D68 associated with paralysis during the 2014 outbreak.Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication.Crystallization and preliminary crystallographic study of Porcine epidemic diarrhea virus main protease in complex with an inhibitorGlobal reemergence of enterovirus D68 as an important pathogen for acute respiratory infections.Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease.Analysis of Enterovirus 68 Strains from the 2014 North American Outbreak Reveals a New Clade, Indicating Viral Evolution.Whole-Genome Sequence Analysis Reveals the Enterovirus D68 Isolates during the United States 2014 Outbreak Mainly Belong to a Novel Clade.Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides.3C Protease of Enterovirus D68 Inhibits Cellular Defense Mediated by Interferon Regulatory Factor 7Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.Enteroviral proteases: structure, host interactions and pathogenicity.The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.RNA-virus proteases counteracting host innate immunity.Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights.The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir.
P2860
Q26753001-7365F8FA-135F-4E4B-B005-A4F635FECDA5Q26798463-ABEEBA17-D0C3-4E72-9545-D24431CE466CQ26992345-9C73CC78-96FE-4BF7-87B2-50CB05627E69Q33660302-622A33CB-E4C7-4C53-B8E7-40E30DB6EB6EQ33743871-21A64366-2C21-4505-B528-A5806B719F5FQ34596364-DDFF5E6E-3F60-49D4-A4F9-0C4EF5FF1060Q34652825-E89825D3-1572-4237-BC92-3BBBAC263558Q35532459-7F761556-F737-45B6-A08A-401051271DF5Q35645639-56C2576B-1FE6-4430-A920-0AFDBA6B5958Q35858982-AA996F3B-BFAC-48C8-8AAD-D4418EB27F66Q36164272-A8F2BD1A-120E-4102-A037-61769779C532Q36290538-14B9883B-AF30-4079-8E30-7C3FD68FAB62Q36421786-74837276-D122-4090-9C5F-46F33632D9E2Q36481457-6C3F8D6F-BE8A-40C9-9252-3FA8D82C2AEDQ36970004-E34131DE-3347-408B-881D-54409B3B0E84Q38825350-0D31BDF1-F465-4AB8-8AEC-8E0F48C389C3Q38988957-4A897566-306B-4836-B331-0320F716941DQ40066626-B582267A-17D2-470F-A88D-D973B72701F4Q40441657-E26E37DD-6936-473A-A430-25B92DA94071Q41175433-D5CF657E-CA86-4DB1-935D-0C3E6C54BA2A
P2860
3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@ast
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@en
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@nl
type
label
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@ast
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@en
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@nl
prefLabel
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@ast
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@en
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@nl
P2093
P2860
P50
P356
P1433
P1476
3C Protease of Enterovirus 68: ...... Effects against Picornaviruses
@en
P2093
Jeroen R Mesters
Jinzhi Tan
Shyla George
Stefan Anemüller
Yuri Kusov
P2860
P304
P356
10.1128/JVI.01123-12
P577
2013-04-01T00:00:00Z