Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis - Test2 - elhamkhani - TriplyDB

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

http://www.wikidata.org/entity/Q27676529

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Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex Targeting Antibiotic Resistance A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome Antibiotics: where to throw the spanner in the ribosomal machinery?Genome sequencing and genomic characterization of a tigecycline-resistant Klebsiella pneumoniae strain isolated from the bile samples of a cholangiocarcinoma patient Mechanism of action of the novel aminomethylcycline antibiotic omadacycline.Total synthesis of viridicatumtoxin B and analogues thereof: strategy evolution, structural revision, and biological evaluation.In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.The bacterial translation stress response.Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution.Tigecycline susceptibility and the role of efflux pumps in tigecycline resistance in KPC-producing Klebsiella pneumoniae.The ribosomal S10 protein is a general target for decreased tigecycline susceptibility Step-Wise Increase in Tigecycline Resistance in Klebsiella pneumoniae Associated with Mutations in ramR, lon and rpsJ Rampant Parasexuality Evolves in a Hospital Pathogen during Antibiotic Selection.Tetracycline does not directly inhibit the function of bacterial elongation factor Tu.Mechanisms of ribosome stalling by SecM at multiple elongation steps.Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors Efflux Pump Overexpression Contributes to Tigecycline Heteroresistance in Salmonella enterica serovar Typhimurium.Prospects for new antibiotics: a molecule-centered perspective.Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance.Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.Antibiotic resistance in Staphylococcus aureus. Current status and future prospects.Tetracycline Antibiotics and Resistance.Bacterial Protein Synthesis as a Target for Antibiotic Inhibition.Recent Advances in the Rational Design and Optimization of Antibacterial Agents.Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.Decreased Susceptibility to Tigecycline Mediated by a Mutation in mlaA in Escherichia coli Strains.NMR assignments of the N-terminal domain of Staphylococcus aureus hibernation promoting factor (SaHPF).Experimental Evolution of Diverse Strains as a Method for the Determination of Biochemical Mechanisms of Action for Novel Pyrrolizidinone Antibiotics.Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets.Mechanisms and fitness costs of tigecycline resistance in Escherichia coli.The Rapid Emergence of Tigecycline Resistance in blaKPC-2 Harboring Klebsiella pneumoniae, as Mediated in Vivo by Mutation in tetA During Tigecycline Treatment.Tetracycline-Inactivating Enzymes.Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism

P2860

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P2860

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

http://www.wikidata.org/entity/Q27676529

description

2013 nî lūn-bûn

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2013 թուականի Մարտին հրատարակուած գիտական յօդուած

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2013年の論文

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Structural basis for potent in ...... cline during protein synthesis

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Proceedings of the National Academy of Sciences of the United States of America

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Structural basis for potent in ...... cline during protein synthesis

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Aleksandra Mikolajka

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Gulnara Yusupova

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Liudmila Filonava

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Marat Yusupov

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P2860

Functional, biophysical, and structural bases for antibacterial activity of tigecycline

Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance

Ribosomal protection proteins and their mechanism of tetracycline resistance

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome.

Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection

The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

Structural aspects of messenger RNA reading frame maintenance by the ribosome

Structural basis for TetM-mediated tetracycline resistance

The structure of the eukaryotic ribosome at 3.0 Å resolution

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10

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110

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235691726

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