A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
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Drugging MYCN through an allosteric transition in Aurora kinase ADevelopment of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase InhibitorsA Novel Approach to the Discovery of Small-Molecule Ligands of CDK2Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent KinasesAurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubulesSequence Determinants of a Specific Inactive Protein Kinase ConformationBase-modified Donor Analogues Reveal Novel Dynamic Features of a GlycosyltransferaseMolecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2Development of novel ACK1/TNK2 inhibitors using a fragment-based approachIdentification and Characterization of an Irreversible Inhibitor of CDK2.An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophaseA water-mediated allosteric network governs activation of Aurora kinase A.Specificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions.Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689.A mixed DFT-MD methodology for the in silico development of drug releasing macrocycles. Calix and thia-calix[N]arenes as carriers for Bosutinib and Sorafenib.The multifaceted allosteric regulation of Aurora kinase A.Dynamics of human protein kinase Aurora A linked to drug selectivity
P2860
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P2860
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@ast
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@en
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@nl
type
label
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@ast
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@en
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@nl
prefLabel
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@ast
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@en
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@nl
P2093
P2860
P356
P1433
P1476
A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
@en
P2093
Ernst Schönbrunn
Harshani R Lawrence
Jin-Yi Zhu
Mathew P Martin
Nicholas J Lawrence
Riazul Alam
Roberta Pireddu
Said M Sebti
Sevil Ozcan
Yunting Luo
P2860
P304
P356
10.1021/CB200508B
P577
2012-04-20T00:00:00Z