Mutational Tipping Points for Switching Protein Folds and Functions
about
Comparing protein folding in vitro and in vivo: foldability meets the fitness challengeConservation of Protein Structure over Four Billion YearsA comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometryLessons from application of the UNRES force field to predictions of structures of CASP10 targetsComputing the relative stabilities and the per-residue components in protein conformational changes.Virtual screening on an α-helix to β-strand switchable region of the FGFR2 extracellular domain revealed positive and negative modulators.The role of negative selection in protein evolution revealed through the energetics of the native state ensemble.Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches.The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein designThe Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.A polymetamorphic protein.Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model.Smooth functional transition along a mutational pathway with an abrupt protein fold switch.Biophysics of protein evolution and evolutionary protein biophysicsHelical ambivalency induced by point mutations.Subdomain interactions foster the design of two protein pairs with ∼80% sequence identity but different folds.The albumin-binding domain as a scaffold for protein engineering.Implication of the cause of differences in 3D structures of proteins with high sequence identity based on analyses of amino acid sequences and 3D structures.Contribution to the prediction of the fold code: application to immunoglobulin and flavodoxin cases.Studying protein fold evolution with hybrids of differently folded homologsPhosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.Distribution and evolution of stable single α-helices (SAH domains) in myosin motor proteinsProtein conformational switches: from nature to design.Comprehensive analysis of sequences of a protein switch.Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions.Multisequence algorithm for coarse-grained biomolecular simulations: Exploring the sequence-structure relationship of proteins.Molecular dynamics simulations on the conformational transitions from the GA 98 (GA 88) to GB 98 (GB 88) proteins.Examination of the quality of various force fields and solvation models for the equilibrium simulations of GA88 and GB88.The energy landscape of a protein switch.Modeling Protein Folding PathwaysGA/GB Fold switching may modulate fatty acid transfer from human serum albumin to bacteria
P2860
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P2860
Mutational Tipping Points for Switching Protein Folds and Functions
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Mutational Tipping Points for Switching Protein Folds and Functions
@ast
Mutational Tipping Points for Switching Protein Folds and Functions
@en
Mutational Tipping Points for Switching Protein Folds and Functions
@nl
type
label
Mutational Tipping Points for Switching Protein Folds and Functions
@ast
Mutational Tipping Points for Switching Protein Folds and Functions
@en
Mutational Tipping Points for Switching Protein Folds and Functions
@nl
prefLabel
Mutational Tipping Points for Switching Protein Folds and Functions
@ast
Mutational Tipping Points for Switching Protein Folds and Functions
@en
Mutational Tipping Points for Switching Protein Folds and Functions
@nl
P2093
P2860
P3181
P1433
P1476
Mutational Tipping Points for Switching Protein Folds and Functions
@en
P2093
Patrick A Alexander
Philip N Bryan
Yihong Chen
P2860
P304
P3181
P356
10.1016/J.STR.2011.11.018
P50
P577
2012-02-08T00:00:00Z