X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor - Test2 - elhamkhani - TriplyDB

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

http://www.wikidata.org/entity/Q27678046

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Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5 Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors Regulation of the MAPK signaling pathway by miR-421-5p in rats under light pollution

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P2860

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

http://www.wikidata.org/entity/Q27678046

description

2013 nî lūn-bûn

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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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type

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X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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prefLabel

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

@ast

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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Journal of Medicinal Chemistry

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X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor

@en

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Jing Wang

http://www.w3.org/2001/XMLSchema#string

Nathanael S Gray

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Nestor Gomez

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Tatiana Erazo

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Xianming Deng

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P2860

Components of a new human protein kinase signal transduction pathway

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway

Primary structure of BMK1: a new mammalian map kinase

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects

Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1

MolProbity: all-atom structure validation for macromolecular crystallography

Knockout of ERK5 causes multiple defects in placental and embryonic development

Crystal structure of human mono-phosphorylated ERK1 at Tyr204

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4413-4421

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scholarly article

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2077848

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10.1021/JM4000837

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11

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56

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Simon J. Arthur

Jonathan M Elkins

Michael Pattison

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2013-05-17T00:00:00Z

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236664632

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23656407

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X-ray crystallography

crystal structure

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3683888

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