Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics - Test2 - elhamkhani - TriplyDB

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

http://www.wikidata.org/entity/Q27678160

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Structure of the Tubulin/FtsZ-Like Protein TubZ from Pseudomonas Bacteriophage ΦKZ FtsZ Protofilaments Use a Hinge-Opening Mechanism for Constrictive Force Generation How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function Structural Change in FtsZ Induced by Intermolecular Interactions between Bound GTP and the T7 Loop Structural reorganization of the bacterial cell-division protein FtsZ from Staphylococcus aureus New insights into TB physiology suggest untapped therapeutic opportunities Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity Variations in the binding pocket of an inhibitor of the bacterial division protein FtsZ across genotypes and species Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets Endless Resistance. Endless Antibiotics?Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor.SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly.A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.Failsafe mechanisms couple division and DNA replication in bacteria.Systems-level antimicrobial drug and drug synergy discovery.Overcoming resistance to β-lactam antibiotics.Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens.BT-benzo-29 inhibits bacterial cell proliferation by perturbing FtsZ assembly.Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid.Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro.TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I.The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).Exposing a chink in the armor of methicillin-resistant Staphylococcus aureus.Methicillin-resistant Staphylococcus aureus in the neonatal intensive care unit An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.A Bacterial Cell Shape-Determining Inhibitor.Design and synthesis of mimics of the T7-loop of FtsZ.Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams.FtsZ-Dependent Elongation of a Coccoid Bacterium Dimer dynamics and filament organization of the bacterial cell division protein FtsA An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivo Thymidylate Limitation Potentiates Cephalosporin Activity toward Enterococci via an Exopolysaccharide-Based Mechanism.Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics.Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

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Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

http://www.wikidata.org/entity/Q27678160

description

2012 nî lūn-bûn

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2012 թուականի Մարտին հրատարակուած գիտական յօդուած

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2012 թվականի մարտին հրատարակված գիտական հոդված

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2012年の論文

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Restoring methicillin-resistan ...... bility to β-lactam antibiotics

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Restoring methicillin-resistan ...... bility to β-lactam antibiotics

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Science Translational Medicine

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Restoring methicillin-resistan ...... bility to β-lactam antibiotics

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Alex G Therien

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Alexandre Caron

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Anastasia Baryshnikova

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Charles J Gill

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Christian Lebeau-Jacob

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Christopher M Tan

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David Claveau

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Eric Langlois

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Etienne Daigneault

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Eugene Maxwell

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Insights on Evolution of Virulence and Resistance from the Complete Genome Analysis of an Early Methicillin-Resistant Staphylococcus aureus Strain and a Biofilm-Producing Methicillin-Resistant Staphylococcus epidermidis Strain

Three decades of beta-lactamase inhibitors

MolProbity: all-atom structure validation for macromolecular crystallography

Refined structure of alpha beta-tubulin at 3.5 A resolution

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity

Refinement of macromolecular structures by the maximum-likelihood method

Features and development of Coot

The CCP4 suite: programs for protein crystallography

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

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Mariana G. Pinho

Pedro Matos Pereira

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221969568

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22440737

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antibiotic resistance

methicillin-resistant Staphylococcus aureus