Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.The enemy within: endogenous retroelements and autoimmune diseaseRationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvantsStructural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGASThe Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation LoopCas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunityDNA sensor cGAS-mediated immune recognitionInnate immune recognition of DNA: A recent historyInternational Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and diseaseCharacterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus ReplicationDissecting How CD4 T Cells Are Lost During HIV InfectionRole of the HIN domain in regulation of innate immune responsesGlutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunityFAM46 proteins are novel eukaryotic non-canonical poly(A) polymerasesThe N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunityMolecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STINGStructure-guided reprogramming of human cGAS dinucleotide linkage specificity.The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STINGIFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMPThe mechanism of double-stranded DNA sensing through the cGAS-STING pathwayMutations in MAB21L2 result in ocular Coloboma, microcornea and cataractsModified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathwayEmerging principles governing signal transduction by pattern-recognition receptorsStructural biology of innate immunity.OASes and STING: adaptive evolution in concertSingle amino acid change in STING leads to constitutive active signaling.Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape.Elucidating Complicated Assembling Systems in Biology Using Size-and-Shape Analysis of Sedimentation Velocity Data.Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling.PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.Inhibition of cGAS DNA Sensing by a Herpesvirus Virion ProteinRing finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing PathwayActivation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseasesSENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.
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P2860
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
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2013 nî lūn-bûn
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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2013 թվականի մայիսին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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prefLabel
Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
@en
Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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P2093
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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity
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Amy Si-Ying Lee
James M Berger
Philip J Kranzusch
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P304
P3181
P356
10.1016/J.CELREP.2013.05.008
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2013-05-30T00:00:00Z