Crystal Structures of EF-G-Ribosome Complexes Trapped in Intermediate States of Translocation
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Structural insights into ribosome translocationSteric interactions lead to collective tilting motion in the ribosome during mRNA-tRNA translocationStructure of the ribosome with elongation factor G trapped in the pretranslocation stateVisualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocationStructures of Yeast 80S Ribosome-tRNA Complexes in the Rotated and Nonrotated ConformationsStructure of EF-G-ribosome complex in a pretranslocation stateThe antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocationCrystal structure of elongation factor 4 bound to a clockwise ratcheted ribosomeAsc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats.Review: Translational GTPasesMajor centers of motion in the large ribosomal RNAsBiased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing.Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.ClustENM: ENM-Based Sampling of Essential Conformational Space at Full Atomic Resolution.EF-G catalyzed translocation dynamics in the presence of ribosomal frameshifting stimulatory signals.Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G.Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments.Mechanism of ribosome translation through mRNA secondary structures.Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis.Direct measurement of the mechanical work during translocation by the ribosome.Nucleolar stress with and without p53.Molecular mechanics of 30S subunit head rotation.Distinct tmRNA sequence elements facilitate RNase R engagement on rescued ribosomes for selective nonstop mRNA decayEF-G and EF4: translocation and back-translocation on the bacterial ribosome.Following movement of domain IV of elongation factor G during ribosomal translocation.Structural dynamics of ribosome subunit association studied by mixing-spraying time-resolved cryogenic electron microscopy.Conformational changes of elongation factor G on the ribosome during tRNA translocationMovement of elongation factor G between compact and extended conformations.Fluorescence-based monitoring of ribosome assembly landscapes.Ribosome excursions during mRNA translocation mediate broad branching of frameshift pathwaysFree-energy landscape of reverse tRNA translocation through the ribosome analyzed by electron microscopy density maps and molecular dynamics simulations.Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.A conserved histidine in switch-II of EF-G moderates release of inorganic phosphate.Structure of BipA in GTP form bound to the ratcheted ribosome.New insights into the enzymatic role of EF-G in ribosome recyclingA dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation.Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation.Structural characterization of ribosome recruitment and translocation by type IV IRES.The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic RibosomeEnsemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
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P2860
Crystal Structures of EF-G-Ribosome Complexes Trapped in Intermediate States of Translocation
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@ast
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@en
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@nl
type
label
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@ast
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@en
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@nl
prefLabel
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@ast
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@en
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@nl
P2093
P2860
P3181
P356
P1433
P1476
Crystal Structures of EF-G-Rib ...... ediate States of Translocation
@en
P2093
Harry F Noller
John Paul Donohue
Laura Lancaster
P2860
P304
P3181
P356
10.1126/SCIENCE.1236086
P407
P577
2013-06-28T00:00:00Z