Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element
about
A family of macrodomain proteins reverses cellular mono-ADP-ribosylationDeficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative diseaseFunctions of PARylation in DNA Damage Repair PathwaysStructures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD DerivativesVisualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activitiesCrystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolaseStructure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureusImplementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.Molecular Insights into Poly(ADP-ribose) Recognition and Processing.Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses.A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.Arabidopsis PARG1 is the key factor promoting cell survival among the enzymes regulating post-translational poly(ADP-ribosyl)ation.Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate.Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors?Reprogramming cellular events by poly(ADP-ribose)-binding proteinsPARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.Macro domains as metabolite sensors on chromatin.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.The recognition and removal of cellular poly(ADP-ribose) signals.Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response.Proteomics approaches to identify mono-(ADP-ribosyl)ated and poly(ADP-ribosyl)ated proteins.The rise and fall of poly(ADP-ribose): An enzymatic perspective.What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities.A novel non-canonical PIP-box mediates PARG interaction with PCNA.Purification of Recombinant Human PARG and Activity Assays.The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
P2860
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P2860
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structure of mammalian poly(AD ...... as a substrate-binding element
@ast
Structure of mammalian poly(AD ...... as a substrate-binding element
@en
Structure of mammalian poly(AD ...... as a substrate-binding element
@nl
type
label
Structure of mammalian poly(AD ...... as a substrate-binding element
@ast
Structure of mammalian poly(AD ...... as a substrate-binding element
@en
Structure of mammalian poly(AD ...... as a substrate-binding element
@nl
prefLabel
Structure of mammalian poly(AD ...... as a substrate-binding element
@ast
Structure of mammalian poly(AD ...... as a substrate-binding element
@en
Structure of mammalian poly(AD ...... as a substrate-binding element
@nl
P2093
P2860
P3181
P356
P1476
Structure of mammalian poly(AD ...... as a substrate-binding element
@en
P2093
Chris M W Ho
In-Kwon Kim
James R Kiefer
John A Tainer
Roderick A Stegeman
Scott Classen
P2860
P2888
P3181
P356
10.1038/NSMB.2305
P577
2012-05-20T00:00:00Z
P5875
P6179
1012125629