Structural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) Inhibitors

Structural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) Inhibitors

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http://www.wikidata.org/entity/Q27679331
The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme targetDiscovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors.Comparison of radii sets, entropy, QM methods, and sampling on MM-PBSA, MM-GBSA, and QM/MM-GBSA ligand binding energies of F. tularensis enoyl-ACP reductase (FabI).Evaluating thermodynamic integration performance of the new amber molecular dynamics package and assess potential halogen bonds of enoyl-ACP reductase (FabI) benzimidazole inhibitors.Bis-indolic compounds as potential new therapeutic alternatives for tularaemia.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Enoyl acyl carrier protein reductase inhibitors: an updated patent review (2011 - 2015).Recent Advances in the Rational Design and Optimization of Antibacterial Agents.Benzimidazole-Based FabI Inhibitors: A Promising Novel Scaffold for Anti-staphylococcal Drug Development.A novel series of enoyl reductase inhibitors targeting the ESKAPE pathogens, Staphylococcus aureus and Acinetobacter baumannii.
P2860

Structural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) Inhibitors

Item
http://www.wikidata.org/entity/Q27679331
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2012 nî lūn-bûn
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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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Structural and Enzymatic Analy ...... yl Reductase (FabI) Inhibitors
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P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932