Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

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http://www.wikidata.org/entity/Q27681412
Compounds for use in the treatment of mycobacterial infections: a patent evaluation (WO2014049107A1).A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR.New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Recycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.The TetR family of regulators.The future for early-stage tuberculosis drug discoveryRecently disclosed chemical entities as potential candidates for management of tuberculosis.Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.Structural and docking studies of potent ethionamide boosters.Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.New active leads for tuberculosis booster drugs by structure-based drug discovery.Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.Selective modification of the 3''-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains.
P2860

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

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http://www.wikidata.org/entity/Q27681412
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
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2012年論文
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2012年论文
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name
Discovery of novel N-phenylphe ...... ughput screening and synthesis
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Discovery of novel N-phenylphe ...... ughput screening and synthesis
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Discovery of novel N-phenylphe ...... ughput screening and synthesis
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type
label
Discovery of novel N-phenylphe ...... ughput screening and synthesis
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Discovery of novel N-phenylphe ...... ughput screening and synthesis
@en
Discovery of novel N-phenylphe ...... ughput screening and synthesis
@nl
prefLabel
Discovery of novel N-phenylphe ...... ughput screening and synthesis
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Discovery of novel N-phenylphe ...... ughput screening and synthesis
@en
Discovery of novel N-phenylphe ...... ughput screening and synthesis
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Discovery of novel N-phenylphe ...... ughput screening and synthesis
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P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921