Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction
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High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein InteractionTargeting protein-protein interactions as an anticancer strategyScreening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonistChallenges and opportunities in targeting the menin-MLL interaction.Targeting protein-protein interfaces using macrocyclic peptides.A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffoldsTargeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?PEPstrMOD: structure prediction of peptides containing natural, non-natural and modified residues.Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand ComplexesTargeting intracellular protein-protein interactions with cell-permeable cyclic peptides.Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan.Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.Biological activities of guanidine compounds, 2008 - 2012 update.Menin: a scaffold protein that controls gene expression and cell signaling.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Formula G1: Cell cycle in the driver's seat of stem cell fate determination.Targeting the MLL complex in castration-resistant prostate cancer.Targeting human SET1/MLL family of proteins.Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.Generation of a cell-permeable cycloheptapeptidyl inhibitor against the peptidyl-prolyl isomerase Pin1.Computational close up on protein-protein interactions: how to unravel the invisible using molecular dynamics simulations?
P2860
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P2860
Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction
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2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structure-based design of high ...... 1) protein-protein interaction
@ast
Structure-based design of high ...... 1) protein-protein interaction
@en
Structure-based design of high ...... 1) protein-protein interaction
@nl
type
label
Structure-based design of high ...... 1) protein-protein interaction
@ast
Structure-based design of high ...... 1) protein-protein interaction
@en
Structure-based design of high ...... 1) protein-protein interaction
@nl
prefLabel
Structure-based design of high ...... 1) protein-protein interaction
@ast
Structure-based design of high ...... 1) protein-protein interaction
@en
Structure-based design of high ...... 1) protein-protein interaction
@nl
P2093
P921
P356
P1476
Structure-based design of high ...... 1) protein-protein interaction
@en
P2093
Alexandro Navarro
Denzil Bernard
Hacer Karatas
Haibin Zhou
Jing Huang
Shaomeng Wang
P304
P356
10.1021/JM3015298
P407
P577
2013-02-14T00:00:00Z