Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage

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http://www.wikidata.org/entity/Q27684014
Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptasePer-residue energy decomposition pharmacophore model to enhance virtual screening in drug discovery: a study for identification of reverse transcriptase inhibitors as potential anti-HIV agentsModeling the functional state of the reverse transcriptase of hepatitis B virus and its application to probing drug-protein interaction.Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamerDouble-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity.HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational PatternA novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase.Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications.Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases.Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
P2860

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage

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http://www.wikidata.org/entity/Q27684014
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2014 nî lūn-bûn
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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2014 թվականի հուլիսին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@ast
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@en
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@nl
type
label
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@ast
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@en
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@nl
prefLabel
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@ast
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@en
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@nl
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P1476
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P304
P31
P3181
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P50
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P5875
P698
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P3181
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P1433
P1476
Structures of HIV-1 RT-RNA/DNA ...... uirements for RNase H cleavage
@en
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P5875
P698
P932