Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases
about
Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical ImplicationsPreclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats.Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction.Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques.Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance.Comparative enzyme inhibition study of 1-deazapurines
P2860
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P2860
Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@ast
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@en
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@nl
type
label
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@ast
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@en
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@nl
prefLabel
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@ast
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@en
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@nl
P2093
P3181
P1476
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
@en
P2093
Charles J Heyser
Gretchen L Snyder
Gyorgy Snell
Hailin Zheng
Hongwen Zhu
J David Beard
Joseph P Hendrick
Kimberly E Vanover
P304
P3181
P356
10.1021/ACS.JMEDCHEM.5B01751
P407
P577
2016-02-02T00:00:00Z