Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

Item
http://www.wikidata.org/entity/Q27703643
Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical ImplicationsPreclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats.Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction.Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques.Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance.Comparative enzyme inhibition study of 1-deazapurines
P2860

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

Item
http://www.wikidata.org/entity/Q27703643
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
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2016年論文
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2016年論文
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2016年論文
@zh-hk
2016年論文
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2016年論文
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2016年论文
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name
Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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type
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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Discovery of Potent and Select ...... and Neuropsychiatric Diseases
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10.1021/ACS.JMEDCHEM.5B01751
P407
P433
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P698
P921