about
S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligandsA Review of the Human Sigma-1 Receptor Structure.Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel.Identification of the gene that codes for the σ2 receptor.Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington diseaseMitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALSSmall molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.Natural Products and Their Mimics as Targets of Opportunity for Discovery.Medicinal Chemistry of σ1 Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Relationships, and Pharmacological Applications.Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signalling.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Targeting Nanocarriers with Anisamide: Fact or Artifact?Are sigma modulators an effective opportunity for cancer treatment? A patent overview (1996-2016).Structural Insights into Sigma1 Function.Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases.Sigma-1 receptor expression in the dorsal root ganglion: Reexamination using a highly specific antibody.On the state of crystallography at the dawn of the electron microscopy revolution.Sigma1 Pharmacology in the Context of Cancer.Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense.APEX2-enhanced electron microscopy distinguishes sigma-1 receptor localization in the nucleoplasmic reticulum.Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa.The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins.Sigma-1 receptor and neuroprotection: current outlook and potential therapeutic effectsRoles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases.Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosaIsolation and characterization of alternatively spliced variants of the mouse sigma1 receptor gene, Sigmar1.Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor.Allosteric Modulation of Opioid G-Protein Coupled Receptors by Sigma1 Receptors.The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma.Cloning the sigma2 receptor: Wandering 40 years to find an identity.Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?Are sigma receptor modulators a weapon against multiple sclerosis disease?Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus.New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.
P2860
Q28818635-22ABB629-F0C2-4614-8A69-A610075CCB05Q30400072-734A6414-304D-416C-A9F3-97A988A7AE02Q33729292-F2028171-424A-42C9-8303-5D9B85C7B190Q33887088-E4366E24-1758-4485-B44A-8D975F64BE4EQ34555731-DD514ABB-3BB2-484D-B6C5-031A90FB82FEQ36183832-7A83E4CD-EB89-4993-AAE8-83AC37DFF84FQ37514803-C52591D4-DBD3-4F90-9D2D-4C184CBB7A1FQ37645771-F4A1230E-0A38-4C4B-A9B1-1103E2EEAAFDQ38557129-F7198D97-1219-4680-B60F-CE49B2CE207EQ38723014-6F3302FB-C3E4-475F-A8EB-23E18ABA5F86Q38758676-982FE110-6F8F-4C24-832C-CC349614FDDDQ38934855-B4A231F1-0F9A-41FA-94B1-60614FB10D75Q39019352-A93A1438-7721-4683-9FCE-075757D3C100Q39067013-6F109CFB-A408-4AD4-ABF5-0F1AA8404B81Q39084919-60F90F1B-10BF-4544-918A-4DC9962324C2Q39153819-F4BC4101-E906-47C6-BEB7-DF603F0767B7Q39169781-C8FEF6CE-3B9B-47F1-9291-C7642670CAE7Q39170894-BBC72D30-196D-4B23-BF5A-509B4E2A5CC5Q39421277-A6267633-2E23-40E8-A6B1-C76A0916D85EQ39458668-FF86B653-E7C4-4B3F-81E6-C066490A65B6Q41532363-120543E1-DFD7-4AC9-9C42-81CB7B8A6D32Q41612758-D5E49C23-64AD-4103-92A0-094628A13BE4Q41632430-8DA50FCC-441F-4305-9A03-BE4E994AFA56Q41636922-CEDC6EAC-BFF1-43E8-90E5-656D2016B5EAQ41647730-EF7A429F-67A3-4F19-A2FA-2727430671FBQ41714466-397AAF29-1358-4A87-835E-F8E5D1EB5B4CQ41716404-C36AA6FB-5148-486F-89FB-23E351735E62Q42056420-4AA7CF6E-4F77-4EBF-AD78-ACB473384E61Q42317501-B4C2EC32-D8A6-46E7-BA0B-7E33C5DC6124Q42330172-1096747B-1E34-4D0F-900C-126B793D49B9Q44346947-0B214A79-EB17-4570-96FC-F8758BA24610Q46413324-41835B6D-C0AA-4C26-B78D-96A7A5F9EFA7Q47109201-D1CA32EB-733D-4C91-950C-0811DC9155E9Q47130202-A5E66297-4B6B-403C-9D38-F17F44F3EBD7Q47153188-CA89EEEC-59B0-4325-BB95-7007771B371FQ47353437-6F5DBE35-CF14-4DFF-8455-B86848A0EC3DQ47596098-B8908060-A0FC-4CB3-A900-244FBA0657A4Q47756273-7F7097B8-2F13-4BE3-8F6F-285AEC779F67Q47773984-DB2F9B4F-CE8B-41DD-9E3E-C64B8BFA0130Q47797929-51A48EEA-5725-4E72-A168-C47D77A85552
P2860
description
2016 nî lūn-bûn
@nan
2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Crystal structure of the human σ1 receptor
@ast
Crystal structure of the human σ1 receptor
@en
Crystal structure of the human σ1 receptor
@nl
type
label
Crystal structure of the human σ1 receptor
@ast
Crystal structure of the human σ1 receptor
@en
Crystal structure of the human σ1 receptor
@nl
prefLabel
Crystal structure of the human σ1 receptor
@ast
Crystal structure of the human σ1 receptor
@en
Crystal structure of the human σ1 receptor
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Crystal structure of the human σ1 receptor
@en
P2093
Aashish Manglik
Andrew C Kruse
Esin Gurpinar
Sanduo Zheng
P2860
P2888
P304
P3181
P356
10.1038/NATURE17391
P407
P577
2016-04-04T00:00:00Z
P6179
1005163175