Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
about
Chemical Proteomic Profiling of Human MethyltransferasesThe U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.The m6A pathway facilitates sex determination in Drosophila.Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.RNA m6A methylation regulates the ultraviolet-induced DNA damage response.The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.Viral Epitranscriptomics.Update: Mechanisms Underlying N6-Methyladenosine Modification of Eukaryotic mRNA.A fly view on the roles and mechanisms of the m6A mRNA modification and its players.The RNA Modification N6-methyladenosine and Its Implications in Human Disease.Dynamic RNA Modifications in Gene Expression Regulation.Structural insights into the molecular mechanism of the m(6)A writer complex.N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles.Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.RNA N6-adenosine methylation (m6A) steers epitranscriptomic control of herpesvirus replicationThe N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.MeT-DB V2.0: elucidating context-specific functions of N6-methyl-adenosine methyltranscriptome.Thiol-linked alkylation of RNA to assess expression dynamics.m6A modulates neuronal functions and sex determination in Drosophila.The Dark Side of the Epitranscriptome: Chemical Modifications in Long Non-Coding RNAs.N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing.METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.N6-Allyladenosine: A New Small Molecule for RNA Labeling Identified by Mutation Assay.m6A Facilitates eIF4F-Independent mRNA Translation.Reading m6A in the Transcriptome: m6A-Binding Proteins.Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance.Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.The emerging role of mRNA methylation in normal and pathological behavior.Rethinking m6A Readers, Writers, and Erasers.Regulatory Role of N6 -methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases.N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?Detection of N6-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease.Interactions, localization and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.mRNA Traffic Control Reviewed: N6-Methyladenosine (m6 A) Takes the Driver's Seat.Human m6A writers: Two subunits, 2 roles.
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P2860
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
description
2016 nî lūn-bûn
@nan
2016 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@ast
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@en
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@nl
type
label
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@ast
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@en
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@nl
prefLabel
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@ast
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@en
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@nl
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P2860
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P3181
P356
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P1476
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
@en
P2093
Delin Zhang
Jinbo Huang
Qiang Wang
Xiang Wang
Zeyuan Guan
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P2888
P304
P3181
P356
10.1038/NATURE18298
P407
P577
2016-05-25T00:00:00Z
P6179
1007258407