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Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models.Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life spanBoth overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster.Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells.Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies.Late-onset dementia: a mosaic of prototypical pathologies modifiable by diet and lifestyle.Adiponectin/adiponectin receptor in disease and aging.Markers of T-cell senescence and physical frailty: insights from Singapore Longitudinal Ageing Studies'Purpose in Life' as a psychosocial resource in healthy aging: an examination of cortisol baseline levels and response to the Trier Social Stress TestThe mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.Fine mapping the CETP region reveals a common intronic insertion associated to HDL-CRole of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulationAmyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids.It takes two to tango: NAD+ and sirtuins in aging/longevity controlIncreased oxidative phosphorylation in response to acute and chronic DNA damage.Time distortions in Alzheimer's disease: a systematic review and theoretical integration.Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function.Metformin decreases progerin expression and alleviates pathological defects of Hutchinson-Gilford progeria syndrome cells.A glimpse at the aging eye.Cytochrome b5 reductase and the control of lipid metabolism and healthspan.Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation.Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.The oxidation state of the cytoplasmic glutathione redox system does not correlate with replicative lifespan in yeastGene expression signatures of human cell and tissue longevity.Lifespan-regulating genes in C. elegans.Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation.Macrophages in age-related chronic inflammatory diseases.Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates.Hsa-miR-520d-5p promotes survival in human dermal fibroblasts exposed to a lethal dose of UV irradiation.Yeast longevity promoted by reversing aging-associated decline in heavy isotope content.Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality.SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes.How does hormesis impact biology, toxicology, and medicine?Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress.Somatic growth, aging, and longevity.Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells.An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites.Aging science comes of age.
P1433
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P1433
description
journal
@en
revista científica
@es
wetenschappelijk tijdschrift van Nature Publishing Group
@nl
wissenschaftliche Fachzeitschrift
@de
name
NPJ aging and mechanisms of disease
@ast
NPJ aging and mechanisms of disease
@en
NPJ aging and mechanisms of disease
@es
NPJ aging and mechanisms of disease
@nl
type
label
NPJ aging and mechanisms of disease
@ast
NPJ aging and mechanisms of disease
@en
NPJ aging and mechanisms of disease
@es
NPJ aging and mechanisms of disease
@nl
altLabel
NPJ Aging Mech Dis
@en
npj Aging and Mechanisms of Disease
@en
npjAMD
@en
prefLabel
NPJ aging and mechanisms of disease
@ast
NPJ aging and mechanisms of disease
@en
NPJ aging and mechanisms of disease
@es
NPJ aging and mechanisms of disease
@nl
P31
P3181
P1055
P1156
21100870831
P1277
P1476
NPJ aging and mechanisms of disease
@en