A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
about
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer modelsTargeting renal cell carcinoma with a HIF-2 antagonist.Hypoxia inducible factors in hepatocellular carcinomaThe hypoxia signalling pathway in haematological malignancies.The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.The therapeutic potential of HIF-2 antagonism in renal cell carcinoma.Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.Targeting HIF2 in Clear Cell Renal Cell Carcinoma.Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.The clinical genetics of phaeochromocytoma and paraganglioma.miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target.Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro.The HIF and other quandaries in VHL disease.Hypoxia and hypoxia-inducible factors in neuroblastoma.A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis.Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics.Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma.Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes.Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB.Renal Cell Carcinoma: Molecular AspectsEndogenous HIF2A reporter systems for high-throughput functional screening
P2860
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P2860
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@ast
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@en
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@nl
type
label
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@ast
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@en
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@nl
prefLabel
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@ast
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@en
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@nl
P2093
P1433
P1476
A Small-Molecule Antagonist of ...... Models of Renal Cell Carcinoma
@en
P2093
Barry S Goggin
Darryl D Dixon
Eli M Wallace
Guangzhou Han
Hanbiao Yang
Huiling Tan
James P Rizzi
John A Josey
Jonas A Grina
P304
P356
10.1158/0008-5472.CAN-16-0473
P407
P577
2016-09-15T00:00:00Z