A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog
about
The Hedgehog protein familyIndian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levelsThe structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingStructural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIPHomozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips.L-arginine recognition by yeast arginyl-tRNA synthetase.Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2ACrystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolutionAn unusual choanoflagellate protein released by Hedgehog autocatalytic processingMapping sonic hedgehog-receptor interactions by steric interferenceCrystal structure of a putative lysostaphin peptidase from Vibrio choleraeThe mode of Hedgehog binding to Ihog homologues is not conserved across different phylaHedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteAll Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerStructural insights into proteoglycan-shaped Hedgehog signalingStructure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogsMutations in the human Sonic Hedgehog gene cause holoprosencephalyA sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patchedMammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehogCrystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.Recursive domains in proteins.Structural trees for protein superfamilies.The NH2-terminal region of the active domain of sonic hedgehog is necessary for its signal transduction.Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.Inference of functional regions in proteins by quantification of evolutionary constraints.Small-molecule modulators of the Sonic Hedgehog signaling pathway.Carboxylate binding modes in zinc proteins: a theoretical studyAsparagine peptide lyases: a seventh catalytic type of proteolytic enzymes.Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex.The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteinsDown-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signalingSmith-Lemli-Opitz syndrome and the DHCR7 gene.Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidaseZinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activationTwo distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions.Hedgehogs like it sweet, too.Structure of a heparin-dependent complex of Hedgehog and Ihog.Hedgehog signaling in hematopoiesis.Answering a century old riddle: brachydactyly type A1.
P2860
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P2860
A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@ast
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@en
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@nl
type
label
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@ast
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@en
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@nl
prefLabel
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@ast
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@en
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@nl
P2093
P356
P1433
P1476
A potential catalytic site rev ...... lling domain of Sonic hedgehog
@en
P2093
P2888
P356
10.1038/378212A0
P407
P577
1995-11-09T00:00:00Z
P5875
P6179
1044116371