Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
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Mithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicityThe three-dimensional structure of the 4:1 mithramycin:d(ACCCGGGT)(2) complex: evidence for an interaction between the E saccharidesCrystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,Molecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent MithramycinThe crucial role of divalent metal ions in the DNA-acting efficacy and inhibition of the transcription of dimeric chromomycin A3Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ionNovel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes.Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novA novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivitySemi-synthetic mithramycin SA derivatives with improved anticancer activity.Dimerization and DNA recognition rules of mithramycin and its analoguesGeneration of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.Structural basis of DNA recognition by anticancer antibiotics, chromomycin A(3), and mithramycin: roles of minor groove width and ligand flexibility.Differential interactions of antitumor antibiotics chromomycin A(3) and mithramycin with d(TATGCATA)(2) in presence of Mg(2+).Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functionsA Dictyostelium protein binds to distinct oligo(dA) x oligo(dT) DNA sequences in the C-module of the retrotransposable element DRE.Small ligands that neither bind to nor alter the structure of d(GA x TC)n sequences in DNA.Chromomycin A2 induces autophagy in melanoma cells.Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex.The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.Chromomycin SA analogs from a marine-derived Streptomyces sp.Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences.Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.Association of antitumor antibiotic Mithramycin with Mn2+ and the potential cellular targets of Mithramycin after association with Mn2+.A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
P2860
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P2860
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@ast
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@en
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@nl
type
label
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@ast
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@en
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@nl
prefLabel
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@ast
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@en
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@nl
P2093
P3181
P356
P1476
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
@en
P2093
P304
P3181
P356
10.1006/JMBI.1995.0464
P407
P577
1995-09-01T00:00:00Z