Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine
about
Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translationDesigner DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognitionVisualisation of extensive water ribbons and networks in a DNA minor-groove drug complexMetal-catalyzed uncaging of DNA-binding agents in living cells†Electronic supplementary information (ESI) available: Synthesis and characterization of the studied molecules and required precursors. NMR, UV, and fluorescence spectra, titrations, contHydration changes in the association of Hoechst 33258 with DNA.A 5-nanosecond molecular dynamics trajectory for B-DNA: analysis of structure, motions, and solvation.Analysis of local helix bending in crystal structures of DNA oligonucleotides and DNA-protein complexes.Antibacterial drug leads: DNA and enzyme multitargetingIn vitro and in vivo antifungal activities of T-2307, a novel arylamidine.Hydration of DNA in aqueous solution: NMR evidence for a kinetic destabilization of the minor groove hydration of d-(TTAA)2 versus d-(AATT)2 segments.The dependence of DNase I activity on the conformation of oligodeoxynucleotides.Anti-Pneumocystis carinii pneumonia activity of dicationic 2,4-diarylpyrimidines.Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding.Hydrogen bond geometry in DNA-minor groove binding drug complexesMetal-catalyzed uncaging of DNA-binding agents in living cells.Structure elucidation of the Pribnow box consensus promoter sequence by racemic DNA crystallography.Sequence-selective binding to DNA of bis(amidinophenoxy)alkanes related to propamidine and pentamidine.Structural and energetic insights into sequence-specific interaction in DNA-drug recognition: development of affinity predictor and analysis of binding selectivity.In vitro, in silico and in vivo analysis of novel aromatic amidines against Trypanosoma cruzi.Validation of a computational docking methodology to identify the non-covalent binding site of ligands to DNA.
P2860
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P2860
Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@ast
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@en
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@nl
type
label
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@ast
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@en
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@nl
prefLabel
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@ast
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@en
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@nl
P2093
P3181
P356
P1433
P1476
Crystal structure of d(CGCGAAT ...... ologue of the drug pentamidine
@en
P2093
P304
P3181
P356
10.1021/BI00213A012
P407
P577
1993-12-21T00:00:00Z