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Mithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicityThe three-dimensional structure of the 4:1 mithramycin:d(ACCCGGGT)(2) complex: evidence for an interaction between the E saccharidesCrystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,Molecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent MithramycinModulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancerThe crucial role of divalent metal ions in the DNA-acting efficacy and inhibition of the transcription of dimeric chromomycin A3Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ionTranscriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins.Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.DNA-binding small molecules as inhibitors of transcription factors.Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis.Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novPCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins.A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivitySemi-synthetic mithramycin SA derivatives with improved anticancer activity.Dimerization and DNA recognition rules of mithramycin and its analoguesGeneration of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone.Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.Structural basis of DNA recognition by anticancer antibiotics, chromomycin A(3), and mithramycin: roles of minor groove width and ligand flexibility.Intra- and intermolecular triplex DNA formation in the murine c-myb proto-oncogene promoter are inhibited by mithramycin.Chromomycin A2 induces autophagy in melanoma cells.Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex.Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29.Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycinThe role of topoisomerases and RNA transcription in the action of the antitumour benzonaphthyridine derivative SN 28049.Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.A 3,4-trans-fused cyclic protecting group facilitates α-selective catalytic synthesis of 2-deoxyglycosides.Chromomycin SA analogs from a marine-derived Streptomyces sp.Role of mg2+ in chromomycin a3 - DNA interaction: a molecular modeling study.Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences.MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.Association of antitumor antibiotic Mithramycin with Mn2+ and the potential cellular targets of Mithramycin after association with Mn2+.
P2860
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P2860
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Solution structure of the mithramycin dimer-DNA complex
@ast
Solution structure of the mithramycin dimer-DNA complex
@en
Solution structure of the mithramycin dimer-DNA complex
@nl
type
label
Solution structure of the mithramycin dimer-DNA complex
@ast
Solution structure of the mithramycin dimer-DNA complex
@en
Solution structure of the mithramycin dimer-DNA complex
@nl
prefLabel
Solution structure of the mithramycin dimer-DNA complex
@ast
Solution structure of the mithramycin dimer-DNA complex
@en
Solution structure of the mithramycin dimer-DNA complex
@nl
P3181
P356
P1433
P1476
Solution structure of the mithramycin dimer-DNA complex
@en
P2093
P304
P3181
P356
10.1021/BI00077A012
P407
P577
1993-07-06T00:00:00Z