Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes
about
Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphatesAlternative modes of binding of proteins with tandem SH2 domainsThe p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complexViral infection and human disease--insights from minimotifsStructural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificityMechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunitThe structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutationsA frequent kinase domain mutation that changes the interaction between PI3K and the membraneAutoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ IsozymesHigh Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28Structural basis for a novel interaction between TXNIP and Vav2A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactionsTyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and AktAssembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.Phosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110.p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110.Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).Specificity and affinity motifs for Grb2 SH2-ligand interactionsCombinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug designExperimental mapping of soluble protein domains using a hierarchical approachStructural basis of nSH2 regulation and lipid binding in PI3Kα.Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling.Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110αInhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domainspH titration studies of an SH2 domain-phosphopeptide complex: unusual histidine and phosphate pKa values.Interaction of class I human leukocyte antigen (HLA-I) molecules with insulin receptors and its effect on the insulin-signaling cascade.Binding specificity of SH2 domains: insight from free energy simulations.Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutantsThe regulation of class IA PI 3-kinases by inter-subunit interactions.Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase.Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects.Insights into structure and function of SHIP2-SH2: homology modeling, docking, and molecular dynamics study.p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin?Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder.The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch.A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes.
P2860
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P2860
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@ast
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@en
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@nl
type
label
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@ast
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@en
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@nl
prefLabel
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@ast
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@en
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@nl
P2093
P2860
P356
P1476
Crystal structure of the PI 3- ...... d its phosphopeptide complexes
@en
P2093
J Schlessinger
S C Harrison
S E Shoelson
P2860
P304
P356
10.1038/NSB0496-364
P577
1996-04-01T00:00:00Z