The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors
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Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activityMolecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinalStructure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoidsThe structural biology of oestrogen metabolismInsights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigationThe crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complex from Agaricus bisporusDirected evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosisThe crystal structure and stereospecificity of levodione reductase from Corynebacterium aquaticum M-13Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientationStructure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenaseThe crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short chain dehydrogenases/reductasesBinary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol productionUnusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenaseCrystal structures of two tropinone reductases: different reaction stereospecificities in the same protein foldConversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestinsStereoselective carveol dehydrogenase from Rhodococcus erythropolis DCL14. A novel nicotinoprotein belonging to the short chain dehydrogenase/reductase superfamilyIdentification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivativeDifferences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acidsIdentification of a mouse short-chain dehydrogenase/reductase gene, retinol dehydrogenase-similar. Function of non-catalytic amino acid residues in enzyme activityMolecular Mechanism of Binding between 17β-Estradiol and DNA.A novel 17beta-hydroxysteroid dehydrogenase in the fungus Cochliobolus lunatus: new insights into the evolution of steroid-hormone signalling.Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures.Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli.Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis.Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development.Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications.Cysteine-10 on 17 β -Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals.Retinol dehydrogenases: membrane-bound enzymes for the visual function.Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man.Aldo-keto reductases in which the conserved catalytic histidine is substitutedElements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1.Inhibitors of type 1 17beta-hydroxysteroid dehydrogenase with reduced estrogenic activity: modifications of the positions 3 and 6 of estradiol.The Bound Structures of 17β-Estradiol-Binding Aptamers.Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1.Identification of Key Residues for Enzymatic Carboxylate Reduction.Design and synthesis of substrate mimetics based on an indole scaffold: potential inhibitors of 17β-HSD type 1.
P2860
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P2860
The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The structure of a complex of ...... s for the design of inhibitors
@ast
The structure of a complex of ...... s for the design of inhibitors
@en
The structure of a complex of ...... s for the design of inhibitors
@nl
type
label
The structure of a complex of ...... s for the design of inhibitors
@ast
The structure of a complex of ...... s for the design of inhibitors
@en
The structure of a complex of ...... s for the design of inhibitors
@nl
prefLabel
The structure of a complex of ...... s for the design of inhibitors
@ast
The structure of a complex of ...... s for the design of inhibitors
@en
The structure of a complex of ...... s for the design of inhibitors
@nl
P2093
P1433
P1476
The structure of a complex of ...... s for the design of inhibitors
@en
P2093
J C Fontecilla-Camps
P304
P356
10.1016/S0969-2126(96)00098-6
P577
1996-08-15T00:00:00Z