Immune mechanisms in malaria: new insights in vaccine developmentGenome-wide and fine-resolution association analysis of malaria in West AfricaEfficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age"Asymptomatic" Malaria: A Chronic and Debilitating Infection That Should Be TreatedFunctional Significance of CD57 Expression on Human NK Cells and Relevance to DiseaseIL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signalsActivation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytesProtective immune responses to the 42-kilodalton (kDa) region of Plasmodium yoelii merozoite surface protein 1 are induced by the C-terminal 19-kDa region but not by the adjacent 33-kDa region.Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan AfricansSerological markers suggest heterogeneity of effectiveness of malaria control interventions on Bioko Island, equatorial GuineaSafety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian ChildrenThe dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in TanzaniaImmunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trialCross-talk with myeloid accessory cells regulates human natural killer cell interferon-gamma responses to malaria.Determination of the processes driving the acquisition of immunity to malaria using a mathematical transmission modelIL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.Piecing together the puzzle of severe malaria.Loss of population levels of immunity to malaria as a result of exposure-reducing interventions: consequences for interpretation of disease trends.Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malariaRapid assessment of malaria transmission using age-specific sero-conversion rates.Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivaxHost Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling.Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent plasmodium falciparum isolates in Ghanaian primigravidae.Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals.Short-lived IFN-γ effector responses, but long-lived IL-10 memory responses, to malaria in an area of low malaria endemicityThe breadth, but not the magnitude, of circulating memory B cell responses to P. falciparum increases with age/exposure in an area of low transmission.Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals.Regulation of antigen-specific immunoglobulin G subclasses in response to conserved and polymorphic Plasmodium falciparum antigens in an in vitro modelEpitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins.Target antigen, age, and duration of antigen exposure independently regulate immunoglobulin G subclass switching in malariaRapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions.Long-lived memory B-cell responses following BCG vaccination.Serologically defined variations in malaria endemicity in Pará state, BrazilCerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis.The relevance of non-human primate and rodent malaria models for humansHuman immune responses that reduce the transmission of Plasmodium falciparum in African populations.The relationship between RTS,S vaccine-induced antibodies, CD4⁺ T cell responses and protection against Plasmodium falciparum infection.Continuing intense malaria transmission in northern Uganda.Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children.Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis.
P50
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lccn-no2015054547