Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
about
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decodingHuman AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survivalHemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNAThe AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNACodon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesTransfer RNA methytransferases and their corresponding modifications in budding yeast and humans: activities, predications, and potential roles in human healthNoncoding RNAs in DNA repair and genome integrityTransfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiaeMethylated nucleosides in tRNA and tRNA methyltransferasesMechanism of activation of methyltransferases involved in translation by the Trm112 'hub' proteinCrystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of lifeThio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems.Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNAAn early step in wobble uridine tRNA modification requires the Elongator complex.The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions.Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteinsA genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae.Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) speciesMultiple Motif Scanning to identify methyltransferases from the yeast proteome.Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-αConservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotesA quantitative systems approach reveals dynamic control of tRNA modifications during cellular stressA comprehensive tRNA deletion library unravels the genetic architecture of the tRNA poolLoss of a Conserved tRNA Anticodon Modification Perturbs Plant ImmunityTrm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased TranslationTrm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeasttRNA biology charges to the fronttRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast.Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)UtRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.Expression and sub-cellular localization of human ABH family molecules.Loss of anticodon wobble uridine modifications affects tRNA(Lys) function and protein levels in Saccharomyces cerevisiae.Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage.
P2860
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P2860
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@ast
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@en
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@nl
type
label
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@ast
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@en
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@nl
prefLabel
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@ast
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@en
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@nl
P2860
P1476
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
@en
P2093
Hamid R Kalhor
Steven Clarke
P2860
P304
P356
10.1128/MCB.23.24.9283-9292.2003
P407
P577
2003-12-01T00:00:00Z