A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.
about
Kynurenines in CNS disease: regulation by inflammatory cytokinesIdentification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1Connecting the dots in Huntington's disease with protein interaction networksGlutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityThe P42 peptide and Peptide-based therapies for Huntington's diseaseTargeting New Candidate Genes by Small Molecules Approaching Neurodegenerative DiseasesRegulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genesMitochondrial targets for pharmacological intervention in human diseaseThe choreography of neuroinflammation in Huntington's diseaseKynurenines in the mammalian brain: when physiology meets pathologyThe flavoproteome of the yeast Saccharomyces cerevisiaeOverexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedbackA genetic screening strategy identifies novel regulators of the proteostasis networkStructural basis of kynurenine 3-monooxygenase inhibitionBiochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogasterThe crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acidThe kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's diseaseOff-target effects of psychoactive drugs revealed by genome-wide assays in yeastAggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assaysProteomic screening for amyloid proteinsAntioxidant Properties of Kynurenines: Density Functional Theory CalculationsMolecular Imaging Markers to Track Huntington’s Disease PathologyTargeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAINGenetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis.Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.Quinolinic acid induced neurodegeneration in the striatum: a combined in vivo and in vitro analysis of receptor changes and microglia activation.Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.Modeling Huntington disease in yeast: perspectives and future directions.Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.Microglial Activation in the Pathogenesis of Huntington's Disease.Mutant huntingtin impairs Ku70-mediated DNA repair.Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSMutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factorsGenome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-β42: importance of lipid homeostasis.Abnormal peripheral chemokine profile in Huntington's diseaseNicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.Ku70 alleviates neurodegeneration in Drosophila models of Huntington's diseaseIdentification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organismsKynurenine pathway inhibition as a therapeutic strategy for neuroprotection.
P2860
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P2860
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A genomic screen in yeast impl ...... target for Huntington disease.
@ast
A genomic screen in yeast impl ...... target for Huntington disease.
@en
A genomic screen in yeast impl ...... target for Huntington disease.
@nl
type
label
A genomic screen in yeast impl ...... target for Huntington disease.
@ast
A genomic screen in yeast impl ...... target for Huntington disease.
@en
A genomic screen in yeast impl ...... target for Huntington disease.
@nl
prefLabel
A genomic screen in yeast impl ...... target for Huntington disease.
@ast
A genomic screen in yeast impl ...... target for Huntington disease.
@en
A genomic screen in yeast impl ...... target for Huntington disease.
@nl
P2093
P2860
P3181
P356
P1433
P1476
A genomic screen in yeast impl ...... target for Huntington disease.
@en
P2093
Flaviano Giorgini
Paolo Guidetti
Paul J Muchowski
QuangVu Nguyen
Simone C Bennett
P2860
P2888
P304
P3181
P356
10.1038/NG1542
P407
P577
2005-05-01T00:00:00Z
P5875
P6179
1003614044