Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin
about
Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actinCoronin is a component of the endocytic collar of hyphae of Neurospora crassa and is necessary for normal growth and morphogenesisIdentification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex.Structural basis for regulation of Arp2/3 complex by GMFA holistic phylogeny of the coronin gene family reveals an ancient origin of the tandem-coronin, defines a new subfamily, and predicts protein functionRole and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complexEmergent Role of Coronin-1a in Neuronal Signaling.Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging.Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filamentsInteractions with actin monomers, actin filaments, and Arp2/3 complex define the roles of WASP family proteins and cortactin in coordinately regulating branched actin networksSite-specific cation release drives actin filament severing by vertebrate cofilin.Cryo-EM reveals different coronin binding modes for ADP- and ADP-BeFx actin filamentsCoronin3 regulates gastric cancer invasion and metastasis by interacting with Arp2.Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAMLActin and endocytosis in budding yeast.Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy.Rapid, optimized interactomic screeningInsertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex.Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASPA Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coroninUnraveling the enigma: progress towards understanding the coronin family of actin regulators.On guard: coronin proteins in innate and adaptive immunity.Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.Towards a molecular understanding of the apicomplexan actin motor: on a road to novel targets for malaria remedies?Structural Basis of Arp2/3 Complex Inhibition by GMF, Coronin, and Arpin.Combinatorial genetic analysis of a network of actin disassembly-promoting factors.Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex.From Phagocytes to Immune Defense: Roles for Coronin Proteins in Dictyostelium and Mammalian Immunity.
P2860
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P2860
Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin
description
2011 nî lūn-bûn
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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
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2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Mechanism of a concentration-d ...... n of Arp2/3 complex by coronin
@ast
Mechanism of a concentration-d ...... n of Arp2/3 complex by coronin
@en
Mechanism of a concentration-d ...... of Arp2/3 complex by coronin.
@nl
type
label
Mechanism of a concentration-d ...... n of Arp2/3 complex by coronin
@ast
Mechanism of a concentration-d ...... n of Arp2/3 complex by coronin
@en
Mechanism of a concentration-d ...... of Arp2/3 complex by coronin.
@nl
prefLabel
Mechanism of a concentration-d ...... n of Arp2/3 complex by coronin
@ast
Mechanism of a concentration-d ...... n of Arp2/3 complex by coronin
@en
Mechanism of a concentration-d ...... of Arp2/3 complex by coronin.
@nl
P2093
P2860
P3181
P356
P1476
Mechanism of a concentration-d ...... n of Arp2/3 complex by coronin
@en
P2093
Brad J Nolen
Jordan R May
Karen M Needham
Su-Ling Liu
P2860
P304
P3181
P356
10.1074/JBC.M111.219964
P407
P577
2011-05-13T00:00:00Z