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Nicotinic ACh receptors as therapeutic targets in CNS disorders

Nicotinic ACh receptors as therapeutic targets in CNS disorders

http://www.wikidata.org/entity/Q28111941

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Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex Cholinergic Nociceptive Mechanisms in Rat Meninges and Trigeminal Ganglia: Potential Implications for Migraine Pain.Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA.α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity Identification and characterization of heptapeptide modulators of the glycine receptor Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large Population-Based Sample.The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.Modulation of aggressive behavior in mice by nicotinic receptor subtypes.A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit Competition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen.From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR.Multiple Small Supernumerary Marker Chromosomes Resulting from Maternal Meiosis I or II Errors Denervated hippocampus provides a favorable microenvironment for neuronal differentiation of endogenous neural stem cells.Cholinergic modulation of the hippocampal region and memory function.Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins.Therapeutic conotoxins: a US patent literature survey.Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease.Tobacco, Nicotine, and Headache.Preclinical Evidence for a Role of the Nicotinic Cholinergic System in Parkinson's Disease.Interactions between the endocannabinoid and nicotinic cholinergic systems: preclinical evidence and therapeutic perspectives.What is the promise of nicotinergic compounds in schizophrenia treatment?Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits.Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.Pharmacological, toxicological and neuronal localization assessment of galantamine/chitosan complex nanoparticles in rats: future potential contribution in Alzheimer's disease management.New drug developments in psychosis: Challenges, opportunities and strategies.Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.Cholinergic/glutamatergic co-transmission in striatal cholinergic interneurons: new mechanisms regulating striatal computation.α9-containing nicotinic acetylcholine receptors and the modulation of pain.The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.Gel Scramble: An E-Tool for Teaching Molecular Neuroscience.Is there a link between passive smoke exposure and early-onset myopia in preschool Asian children?Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins.Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli.

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

http://www.wikidata.org/entity/Q28111941

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2015 nî lūn-bûn

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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2015 թվականի փետրվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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type

label

Nicotinic ACh receptors as therapeutic targets in CNS disorders

@ast

Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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J.TIPS.2014.12.002

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Trends in Pharmacological Sciences

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Nicotinic ACh receptors as therapeutic targets in CNS disorders

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Anshul A Pandya

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Jerrel L Yakel

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Kelly T Dineley

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P2860

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Allosteric modulator Desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-amyloid(1-42) peptide

Mammalian nicotinic acetylcholine receptors: from structure to function

Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures

Rethinking inflammation: neural circuits in the regulation of immunity.

Crystal structure of a human GABAA receptor

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

Molecular actions of smoking cessation drugs at 4 2 nicotinic receptors defined in crystal structures of a homologous binding protein

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