about
Reactivation of telomerase in cancerUncertainty in integrative structural modelingProgress in structural studies of telomeraseThe shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7Many disease-associated variants of hTERT retain high telomerase enzymatic activityInventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.Identification of human TERT elements necessary for telomerase recruitment to telomeres.Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Human telomerase: biogenesis, trafficking, recruitment, and activation.Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.Structural biology: a solution to the telomerase puzzle.L1 retrotransposition: The snap-velcro model and its consequencesTelomerase structure.Reduced hTERT protein levels are associated with DNA aneuploidy in the colonic mucosa of patients suffering from longstanding ulcerative colitis.Coordinated DNA dynamics during the human telomerase catalytic cycle.Telomere maintenance mechanisms in cancer: clinical implicationsStructure and mechanism of action of the BRCA2 breast cancer tumor suppressorA Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.Monovalent Strep-Tactin for strong and site-specific tethering in nanospectroscopy.Telomeric G-quadruplexes are a substrate and site of localization for human telomeraseAssociations of TERC Single Nucleotide Polymorphisms with Human Leukocyte Telomere Length and the Risk of Type 2 Diabetes Mellitus.Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes.Structural and functional consequences of a disease mutation in the telomere protein TPP1.Current Insights to Regulation and Role of Telomerase in Human Diseases.An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532A combination of the telomerase inhibitor, BIBR1532, and paclitaxel synergistically inhibit cell proliferation in breast cancer cell lines.Quantitative assessment of telomerase components in cancer cell lines.Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes.Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis.Progress in Human and Tetrahymena Telomerase Structure Determination.Single-Molecule Studies of Telomeres and Telomerase.The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo.HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B.Structural biology of telomerase and its interaction at telomeres.Crystallographic Studies of Telomerase.Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly.Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress.Dynamics of human telomerase recruitment depend on template- telomere base pairing.Label-free ultrasensitive detection of telomerase activity via multiple telomeric hemin/G-quadruplex triggered polyaniline deposition and a DNA tetrahedron-structure regulated signal.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structure of active dimeric human telomerase
@nl
Structure of active dimeric human telomerase.
@ast
Structure of active dimeric human telomerase.
@en
type
label
Structure of active dimeric human telomerase
@nl
Structure of active dimeric human telomerase.
@ast
Structure of active dimeric human telomerase.
@en
prefLabel
Structure of active dimeric human telomerase
@nl
Structure of active dimeric human telomerase.
@ast
Structure of active dimeric human telomerase.
@en
P2093
P2860
P356
P1476
Structure of active dimeric human telomerase.
@en
P2093
Anselm Sauerwald
Daniela Rhodes
Joachim Lingner
Sara Sandin
Sjors H W Scheres
P2860
P2888
P304
P356
10.1038/NSMB.2530
P577
2013-03-10T00:00:00Z