Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins - Test2 - elhamkhani - TriplyDB

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.wikidata.org/entity/Q28115540

about

Kufs disease, the major adult form of neuronal ceroid lipofuscinosis, caused by mutations in CLN6 Distinct early molecular responses to mutations causing vLINCL and JNCL presage ATP synthase subunit C accumulation in cerebellar cells Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis.Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy.Induced Pluripotent Stem Cells Derived from a CLN5 Patient Manifest Phenotypic Characteristics of Neuronal Ceroid Lipofuscinoses.The juvenile Batten disease protein, CLN3, and its role in regulating anterograde and retrograde post-Golgi trafficking.Proteomic Profiling in the Brain of CLN1 Disease Model Reveals Affected Functional Modules.Proteolytic processing of the neuronal ceroid lipofuscinosis related lysosomal protein CLN5.Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice.Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation.Therapeutic approaches to the challenge of neuronal ceroid lipofuscinoses.Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.Neuronopathic lysosomal storage diseases: clinical and pathologic findings.Topology and membrane anchoring of the lysosomal storage disease-related protein CLN5.CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches.Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers.The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells.Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?High expression of disease-related Cln6 in the cerebral cortex, purkinje cells, dentate gyrus, and hippocampal ca1 neurons.Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation.

P2860

0423cf4663e4fad62266c7135519cf69cfc2444a 046aaab9db371d8f8c97895a7072969e913bb527 1402a0318778bba55809079bd7b043afe9b36fb9 1e1c98bcffee8ee92bdaddd4d2d46e2336e6c246 1ef35f13ac4a1e19e7a403e0a1230edc9b030b7f 1f6bdb47c6079d37c17f002a0f9a480ab164aa63 21dd711b6f4c00734a1c1f442587b1147d2b18d7 265c8b3a60bde11c6e6bda114b745c8cc30d6b0d 35c81e20a6880f6b4923b2849ce2780fe894cc7b 45b193bfeb5f50a192f22c402874b785649a6bf6 47e38303f721a339d29504deedef2f16295c6cb6 5a457fd7f9aa3bd5bb2fa05c18fb970ed9179f5c 5b447f3daa31cd682265ec074ed2b738fb023507 5e09f410ee414dc1627d270d7af3ce18792de047 6ed861f879f0e656aa2784083e33c69472c748ed 7ef5fb293eee2a01859add6c823650ac01c5a7c7 83bf646cf11dd93d0b996d4b17d90fbb4aeae0c1 933610151a7d03735e231686fc603d8041193fec 944168b9de1b20b278b7d4e841169a2dd37cf602 9f952367f498ef4f2b4d246beb73c206bfbd9b01 a8c36a3e365fa6ae649ea3b85f0e246d87b821d0 b33c982460cf438fcc97cb821dad40c3f55f8985 beb215794b2e7a780213740f919360d5b2ba9924 cdd25dce42481d670fa1127f323fb0888a61f028 e4515e1969b3d481694c27fc9bb00479f79a965a e50c638fad5045f70ec0062497d08e092c6982c9 e5a45498d35ee3dae721114015d47804bdfea151

P248

Q24626677-0A3AB9E3-9B0E-42AE-B644-ED8635371C7D Q27354870-97A7D77F-824D-4F03-945E-F4B34AC0D7FF Q28289653-19CEB3E1-57BA-499F-8B5B-FD5F03D04FEA Q28589863-D7441B1E-782F-4411-93FB-460A66D74793 Q28708978-39E4A1B9-C712-44EA-8B0B-03D761076540 Q30496353-F567BE2E-FF18-4DE0-AAE5-E882B5DF2E1D Q33686331-5FCA379C-B65B-4D08-9738-EFD87CF24073 Q33754927-74E25E26-BD78-4EC2-8236-69C5DD4CA753 Q34271805-97FCA440-0FF7-43B4-91E2-02B7569F0FDB Q35879035-C93C8329-A0D5-44AD-B917-78C8739DDCF7 Q36109195-F165AD61-D02E-4EB8-8A93-96E88FE683CE Q36683039-DBB82871-408B-4DAF-A5ED-F80D91EC2401 Q36685260-75DC315E-D6CA-40B7-94DE-E3F28FD43993 Q36784566-4307CFD2-5735-4705-BAA8-E0469C61CFB6 Q37649077-897096E3-F0C1-4183-9D62-C82F23A4D0CE Q37944570-5199DA2D-7660-4C62-AE1E-0F5DA99B9EFD Q38116812-146CE281-42AE-4EB5-A1F3-E75C551FC0DC Q39095656-C6C868D0-416A-4187-A005-3B6CAF0AC507 Q39243050-F11A5A02-A67E-4EF8-A6BF-BF679218E48C Q39646522-3075D2A9-485D-463A-8461-E82DDE49DE6F Q41525295-B3CF82A2-954E-4144-972B-7F11F59E14D6 Q48788268-6A21A786-F6C8-4868-A317-B1778FEDDCE7 Q48829631-D6D281DD-5F7F-4FB8-B408-BB3AF925AC49 Q52364277-7FE017F3-4ADD-4B30-BCF7-E041A261EEA9

P2860

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.wikidata.org/entity/Q28115540

description

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2009

@ast

im November 2009 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2009/11/26)

@sk

vědecký článek publikovaný v roce 2009

@cs

wetenschappelijk artikel (gepubliceerd op 2009/11/26)

@nl

наукова стаття, опублікована в листопаді 2009

@uk

مقالة علمية (نشرت في 26-11-2009)

@ar

name

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@ast

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@en

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@nl

type

label

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@ast

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@en

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@nl

prefLabel

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@ast

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@en

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@nl

P1433

Q28115540-822DF0C2-9CC2-41BB-ADBE-EF25EA8344F5

P1476

Q28115540-7E29EB29-CDCE-4ECC-B83E-B63698503E3B

P2093

Q28115540-163DD6CD-EFB3-4858-8AAC-61C84BDBD1EE

Q28115540-210D7BD3-0D26-4A37-815B-D5ACA3B37C10

Q28115540-3FF9D466-12C6-4764-B4BB-3DD6A8656029

Q28115540-A095F888-B33A-43B4-AE64-0209FD777864

Q28115540-CC131151-7507-4704-9BBC-09BA378A47C2

Q28115540-CDEDDA51-ADCC-43E5-89CC-18B9003A9E63

P2860

Q28115540-0379692F-866B-4D83-9C8E-FEE13C294FC2

Q28115540-05F7096F-E489-4BB7-8121-4D4B2C64EE44

Q28115540-0A98B92B-83E2-4FA2-A3F8-CB01D27CD08C

Q28115540-100A0726-D222-41CF-B928-08F5D9DA2AD1

Q28115540-12068F2D-B654-4362-B4B3-1C0646D9E8EB

Q28115540-1489A541-26B6-44A3-8BC7-2BB75E333095

Q28115540-16AA3009-2D23-48ED-AC2D-760A0F2938E8

Q28115540-1B0B516F-F6BD-4B07-8DC3-AEF6ED028A48

Q28115540-22058811-ABEA-440A-8324-715EBE6E0BB8

Q28115540-224DDEDF-07A2-4B8D-ACA6-E53EE7AF2864

P2888

Q28115540-8EB7753C-D06A-4D8F-BC5F-D550647FC1F2

P304

Q28115540-1B03EF92-E32B-46D7-8572-4F8F4D21A11A

P31

Q28115540-37892D4D-A075-431D-BB95-2F968E1CF0A4

P356

Q28115540-914267BF-C9B5-4234-9923-ED44B1AA1F66

P478

Q28115540-F604764A-1C8D-41DE-914D-1BEE5CD74226

P50

Q28115540-F9A52924-5CD4-4308-B7DC-86C6F7B42B32

P577

Q28115540-9BA7F271-4FFD-43F2-81CF-A31C6FF62236

P5875

Q28115540-E40D6CD3-1B38-416B-908B-E824B6E34CB1

P6179

Q28115540-AF9BE8FE-221C-4E7B-BB9D-258D49F29BDD

P698

Q28115540-E1E23D94-3BA2-4874-A0DE-01C96F9580A8

P921

Q28115540-025952F1-C1DD-4FE6-892F-A0985AB70D72

Q28115540-08FA344E-BF7E-4C7D-AD99-1E0E0AB4C0DB

Q28115540-208F7BC7-8AF7-4F92-BD7A-5E03017EA142

Q28115540-2305F20B-11AF-4253-86E6-3A33C8FEA04C

Q28115540-349ACBF8-CA98-4A07-9060-D86E69520D49

Q28115540-379651ED-C459-43D2-82B9-B1EEBDA5E2AD

Q28115540-3BB1CF27-9F3E-494C-BA2D-7242402777AE

Q28115540-3F83E809-44E2-404D-BCEC-E6DB31C1CC89

Q28115540-53EF9D7C-1206-41E4-82AB-C48974880A59

Q28115540-7CE34495-CA73-40FC-9B7D-6F80B441EDC5

P932

Q28115540-979D6295-A777-44B1-9E17-78CB0EECBDC2

P356

1471-2121-10-83

P1433

BMC Cell Biology

P1476

Novel interactions of CLN5 sup ...... Ceroid Lipofuscinosis proteins

@en

P2093

Aija Kyttälä

http://www.w3.org/2001/XMLSchema#string

Annina Lyly

http://www.w3.org/2001/XMLSchema#string

Carina von Schantz

http://www.w3.org/2001/XMLSchema#string

Claudia Heine

http://www.w3.org/2001/XMLSchema#string

Mia-Lisa Schmiedt

http://www.w3.org/2001/XMLSchema#string

Tessa Sipilä

http://www.w3.org/2001/XMLSchema#string

P2860

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons

The neuronal ceroid lipofuscinosis CLN8 membrane protein is a resident of the endoplasmic reticulum

CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain

Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)

CLN3 protein is targeted to neuronal synapses but excluded from synaptic vesicles: new clues to Batten disease

Lysosomal localization of the neuronal ceroid lipofuscinosis CLN5 protein

CLN6, which is associated with a lysosomal storage disease, is an endoplasmic reticulum protein

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3

TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

P2888

1471-2121-10-83

P304

83

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1186/1471-2121-10-83

http://www.w3.org/2001/XMLSchema#string

P478

10

http://www.w3.org/2001/XMLSchema#string

P50

P577

2009-11-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

40034816

http://www.w3.org/2001/XMLSchema#string

P6179

1049799100

http://www.w3.org/2001/XMLSchema#string

P698

19941651

http://www.w3.org/2001/XMLSchema#string

P921

Ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)

CLN3 lysosomal/endosomal transmembrane protein, battenin

CLN5 intracellular trafficking protein

CLN6 transmembrane ER protein

CLN8 transmembrane ER and ERGIC protein

Palmitoyl-protein thioesterase 1

Tripeptidyl peptidase 1

Ceroid-lipofuscinosis, neuronal 5

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1

CLN8 transmembrane ER and ERGIC protein

P932

2790443

http://www.w3.org/2001/XMLSchema#string