Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa
about
The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating complex.Recombinant Factor IX Fc Fusion Protein Maintains Full Procoagulant Properties and Exhibits Prolonged Efficacy in Hemophilia B Mice.Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B.Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B.Therapeutic plasma proteins--application of proteomics in process optimization, validation, and analysis of the final product.Coagulation Factor IX for Hemophilia B Therapy.Identification of functionally important residues of the epidermal growth factor-2 domain of factor IX by alanine-scanning mutagenesis. Residues Asn(89)-Gly(93) are critical for binding factor VIIIa.The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa.The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex.Enhancement of human protein C function by site-directed mutagenesis of the gamma-carboxyglutamic acid domain.
P2860
Q34102427-D0242F06-7BB8-4344-BDE0-BEF13B0FC298Q35913495-38BC9EDB-533A-4C34-A0FA-6399DC2421A0Q36037525-223C432B-5998-44FC-80B5-B0E33D1841AEQ37371257-471E9FA1-F6C7-4A59-A5B7-FA224D2D4C37Q37872258-9552E514-9D1C-4574-8133-5931B2521E72Q42256024-B88EB221-4861-49B2-A3B0-E91C25B1DA81Q43964485-AB4484CD-1795-4129-ADBE-71F05A966E25Q44463045-EBE52C2D-D9BF-418F-A46D-8F53D370E517Q45858909-BF6EBCC5-22BE-4309-93F5-DEEB56EE13DAQ46220531-2EFA9324-A1ED-4550-ABFD-2A61787BEAF3Q54117223-F84FD6E1-A0F7-4505-B013-30BC70103684
P2860
Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa
description
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im Februar 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/02/16)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/02/16)
@nl
наукова стаття, опублікована в лютому 1996
@uk
name
Structural integrity of the ga ...... its binding to cofactor VIIIa
@ast
Structural integrity of the ga ...... its binding to cofactor VIIIa
@en
Structural integrity of the ga ...... its binding to cofactor VIIIa
@nl
type
label
Structural integrity of the ga ...... its binding to cofactor VIIIa
@ast
Structural integrity of the ga ...... its binding to cofactor VIIIa
@en
Structural integrity of the ga ...... its binding to cofactor VIIIa
@nl
prefLabel
Structural integrity of the ga ...... its binding to cofactor VIIIa
@ast
Structural integrity of the ga ...... its binding to cofactor VIIIa
@en
Structural integrity of the ga ...... its binding to cofactor VIIIa
@nl
P2093
P2860
P921
P356
P1476
Structural integrity of the ga ...... its binding to cofactor VIIIa
@en
P2093
C. K. Kasper
D. M. Monroe
K. A. High
K. J. Smith
P. J. Larson
S. A. Stanfield-Oakley
W. J. VanDusen
P2860
P304
P356
10.1074/JBC.271.7.3869
P407
P577
1996-02-16T00:00:00Z