Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
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The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.The m6A pathway facilitates sex determination in Drosophila.m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.Update: Mechanisms Underlying N6-Methyladenosine Modification of Eukaryotic mRNA.The RNA Modification N6-methyladenosine and Its Implications in Human Disease.Dynamic RNA Modifications in Gene Expression Regulation.Structural insights into the molecular mechanism of the m(6)A writer complex.N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles.Epitranscriptomic influences on development and disease.The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.Mutations in RNA methylating enzymes in disease.Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs.m6A modulates neuronal functions and sex determination in Drosophila.The Dark Side of the Epitranscriptome: Chemical Modifications in Long Non-Coding RNAs.N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing.METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.m6A Facilitates eIF4F-Independent mRNA Translation.Reading m6A in the Transcriptome: m6A-Binding Proteins.Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.The emerging role of mRNA methylation in normal and pathological behavior.Rethinking m6A Readers, Writers, and Erasers.Regulatory Role of N6 -methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases.N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?N6-methyladenosine links RNA metabolism to cancer progression.Detection of N6-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease.Interactions, localization and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.Impact of DNA and RNA Methylation on Radiobiology and Cancer Progression.mRNA Traffic Control Reviewed: N6-Methyladenosine (m6 A) Takes the Driver's Seat.Human m6A writers: Two subunits, 2 roles.Structural insights into the RNA methyltransferase domain of METTL16.Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders.Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism.
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P2860
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
description
2016 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2016
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im Juli 2016 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2016/07/21)
@sk
vědecký článek publikovaný v roce 2016
@cs
wetenschappelijk artikel (gepubliceerd op 2016/07/21)
@nl
наукова стаття, опублікована в липні 2016
@uk
مقالة علمية (نشرت في 21-7-2016)
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name
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@ast
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@en
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
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type
label
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@ast
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@en
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@nl
prefLabel
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@ast
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@en
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@nl
P2093
P2860
P921
P3181
P1433
P1476
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
@en
P2093
Katelyn A. Doxtader
Yunsun Nam
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2016.05.041
P577
2016-07-21T00:00:00Z