Adapting proteostasis for disease intervention - Test2 - elhamkhani - TriplyDB

Adapting proteostasis for disease intervention

Adapting proteostasis for disease intervention

http://www.wikidata.org/entity/Q28131818

about

Molecular Chaperones as Targets to Circumvent the CFTR Defect in Cystic Fibrosis Ubiquitin-proteasome system involvement in Huntington's disease Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1 Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns Increased proteasome activity in human embryonic stem cells is regulated by PSMD11 Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation Interplay of LRRK2 with chaperone-mediated autophagy Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins Sustained translational repression by eIF2α-P mediates prion neurodegeneration The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction Altered ribostasis: RNA-protein granules in degenerative disorders Prions, protein homeostasis, and phenotypic diversity Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency Dynamic dissociating homo-oligomers and the control of protein function Spatial protein quality control and the evolution of lineage-specific ageing Aging as an event of proteostasis collapse Mechanism of folding chamber closure in a group II chaperonin α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging Recombinant prion protein induces a new transmissible prion disease in wild-type animals.Misfolded proteins partition between two distinct quality control compartments Shape shifting leads to small-molecule allosteric drug discovery NPC1/NPC2 function as a tag team duo to mobilize cholesterol Protein homeostasis and aging: taking care of proteins from the cradle to the grave Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations Molecular chaperones: guardians of the proteome in normal and disease states Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis Hsp90: A New Player in DNA Repair?Protein Folding and Mechanisms of Proteostasis Expanding proteostasis by membrane trafficking networks

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P2860

Adapting proteostasis for disease intervention

http://www.wikidata.org/entity/Q28131818

description

2008 nî lūn-bûn

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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2008 թվականի փետրվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Adapting proteostasis for disease intervention

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Adapting proteostasis for disease intervention

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Adapting proteostasis for disease intervention

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Adapting proteostasis for disease intervention

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Adapting proteostasis for disease intervention

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SCIENCE.1141448

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Adapting proteostasis for disease intervention

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Andrew Dillin

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Richard I Morimoto

http://www.w3.org/2001/XMLSchema#string

William E Balch

http://www.w3.org/2001/XMLSchema#string

P2860

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

Signal integration in the endoplasmic reticulum unfolded protein response

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis

The mammalian unfolded protein response

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

The plasticity of aging: insights from long-lived mutants

Two neurons mediate diet-restriction-induced longevity in C. elegans

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10.1126/SCIENCE.1141448

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5865

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319

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Jeffery W. Kelly

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