about
Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cellsMdm2 targets the p53 transcription cofactor JMY for degradationTip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiationMDM2-HDAC1-mediated deacetylation of p53 is required for its degradationProapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyDistinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineageUse of Immunomatrix Methods to Improve Protein-Protein Interaction Detectionp14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls.Modulation of Protein-Protein Interactions for the Development of Novel TherapeuticsInvolvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical DevelopmentDiscovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical DevelopmentThe genetics of the p53 pathway, apoptosis and cancer therapy.Emerging Non-Canonical Functions and Regulation by p53: p53 and StemnessMultiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domainsNFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damagePhosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cellsActivation and activities of the p53 tumour suppressor proteinp53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemA synthetic form of frizzled 8-associated antiproliferative factor enhances p53 stability through USP2a and MDM2Human serum albumin and p53-activating peptide fusion protein is able to promote apoptosis and deliver fatty acid-modified moleculesSignificant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug TreatmentDesign, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 InteractionIdentification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin DA novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2p53 ubiquitination: Mdm2 and beyondIdentification of a CK2 phosphorylation site in mdm2.Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) geneC-terminal ubiquitination of p53 contributes to nuclear exportDiscovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine DoubleRegulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.Targeting p53 for Novel Anticancer Therapy.Hairless expression attenuates apoptosis in a mouse model and the COS cell line; involvement of p53.Autoantibody response to murine double minute 2 protein in immunodiagnosis of hepatocellular carcinoma.A theoretical exploration of birhythmicity in the p53-Mdm2 network.MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
P2860
Q23918117-022E002B-4413-4C60-BDE2-223B0916E476Q24337019-437733CC-2162-45BB-83BC-53B0B4606D6BQ24536285-F03B6A9C-62B2-4715-8D58-74A4B2D36783Q24537700-3E41FAB1-E366-44E1-A049-3DA2E49C207EQ24551160-5655E6B2-2D93-44BB-A409-36B31984FF4CQ24651380-D3E56E8B-E787-4707-887A-F03C5DD7153DQ24678598-EC1CA2F3-1631-4483-B75C-026772AF92C8Q24799379-3F21DE2B-B946-4BB2-BB8E-4FEB47CED065Q24806368-FAA9EF59-AB53-4CD7-B616-08704AACBF72Q24816168-CF421781-5CF3-43F1-AE5D-86FDD267F751Q26775356-03FF3692-2BB0-47DD-96CA-756EDAE677E1Q27002581-0ECC895B-FD71-44CE-B728-63D2E6D3DF51Q27006998-151F9FD7-9DEA-47ED-9319-826EE6EAC25AQ27684199-CD2D8475-9FEE-4E88-B2ED-03AD52078D99Q27684218-6F6F0513-4B36-40DA-888A-CACC1AFBA8D4Q27863460-67FFD8FA-2D34-48E9-9861-12942E52E114Q28077156-45DAD78D-71CC-4AAA-A11A-7AE2C6B12E1FQ28142503-111CBE41-5280-4433-BAF4-19820508384CQ28304255-8DF66245-8D5A-4CEA-95DC-A436D9C078D6Q28361800-7DE728AB-4812-4550-A963-329E51AEC529Q28366563-98391A82-7FEF-40CA-8993-560FA3276266Q28478414-7CD4751B-FB7B-46BC-A266-3F4C196EB4C4Q28485503-585D6878-E682-4A76-8362-A29EE72C946CQ28535347-87D391CE-CBE7-4D83-A828-C1492D2BAD24Q28548249-342EBB06-109F-4B22-8F84-B82A32106A73Q28548694-2C00DCAE-45A3-41B8-B4D9-74064A3086DCQ28565709-B4EFFFD9-331B-4448-9FE2-67C516E48169Q28588691-2FC09CA5-DF3F-4E38-AA18-B0CEF17A77E9Q29619502-4D4FC83E-F584-48A4-8784-5BAE4AAEAD19Q30812794-70D5630B-7D8F-442A-BF3A-7B6311A485D4Q33330479-D78A447E-2983-4BC3-8C21-A4BB590E3205Q33551236-6BBDD54A-F512-41EF-B4A4-656FA952EA59Q33572704-1623F4CB-3DDB-42E5-BBB9-9B7E41ACFD45Q33588288-F06D7B3F-50B0-49A2-917E-124789BADBF1Q33655329-23697A34-6982-445C-89BA-C14F3F48E03BQ33707780-D790C2BE-A28C-4D83-B036-E08CA5ECD350Q33739952-07F49940-14CF-4771-AB91-4B56D6EA2048Q33826269-C8AD6405-FC00-4459-95D5-833CABEFCCD0Q33915624-68032110-ECE9-442E-86CF-A28F2FA4C6E6Q33944754-B15CA447-81A5-4417-BF43-EE3A0FDABFAD
P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Functions of the MDM2 oncoprotein
@ast
Functions of the MDM2 oncoprotein
@en
Functions of the MDM2 oncoprotein
@nl
type
label
Functions of the MDM2 oncoprotein
@ast
Functions of the MDM2 oncoprotein
@en
Functions of the MDM2 oncoprotein
@nl
prefLabel
Functions of the MDM2 oncoprotein
@ast
Functions of the MDM2 oncoprotein
@en
Functions of the MDM2 oncoprotein
@nl
P2093
P3181
P356
P1476
Functions of the MDM2 oncoprotein
@en
P2093
P2888
P304
P3181
P356
10.1007/S000180050273
P407
P577
1999-01-01T00:00:00Z