about
Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteinsLigand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cellsExternal control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivatorTTD: Therapeutic Target DatabaseLeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptakeIdentification of a chemical probe for NAADP by virtual screeningHigh-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptorA database for G proteins and their interaction with GPCRsA surrogate-based approach for post-genomic partner identificationGenome wide survey of G protein-coupled receptors in Tetraodon nigroviridis.High-throughput kinase assays with protein substrates using fluorescent polymer superquenchingStructure modeling of all identified G protein-coupled receptors in the human genomeProtein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor DiscoveryPhenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery PerspectivesMetabolomics, Standards, and Metabolic Modeling for Synthetic Biology in PlantsTwo-Dimensional Crystallization Procedure, from Protein Expression to Sample PreparationThe Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine MicroorganismsFine-tuning multiprotein complexes using small moleculesPolymer-conjugated inhibitors of tumor necrosis factor-α for local control of inflammationApplications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseasesThe magic of bicelles lights up membrane protein structureStructural DNA nanotechnology: state of the art and future perspectiveDrugs derived from phage display: from candidate identification to clinical practiceSystems genetics for drug target discoveryNanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteinsElucidation of New Binding Interactions with the Human Tsg101 Protein Using Modified HIV-1 Gag-p6 Derived Peptide LigandsEvidence for Follicle-stimulating Hormone Receptor as a Functional TrimerTetrahydrobiopterin biosynthesis as an off-target of sulfa drugsUnderstanding functional residues of the cannabinoid CB1.Muddled mechanisms: recent progress towards antimalarial target identificationNovel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding SiteA New Ethical Challenge for Institutional Review Boards (IRBs)/Ethics Committees (ECs) in the Assessment of Pediatric Clinical TrialsInnovative cancer drug targets: genomics, transcriptomics and clinomicsDeletion of Gpr128 results in weight loss and increased intestinal contraction frequencyA dual-color fluorescence-based platform to identify selective inhibitors of Akt signalingBlood peptidome-degradome profile of breast cancerPrediction of disease-related interactions between microRNAs and environmental factors based on a semi-supervised classifierAn antitubulin agent BCFMT inhibits proliferation of cancer cells and induces cell death by inhibiting microtubule dynamicsDevelopment of a high-throughput three-dimensional invasion assay for anti-cancer drug discoveryComparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Drug discovery: a historical perspective
@ast
Drug discovery: a historical perspective
@en
Drug discovery: a historical perspective
@nl
type
label
Drug discovery: a historical perspective
@ast
Drug discovery: a historical perspective
@en
Drug discovery: a historical perspective
@nl
prefLabel
Drug discovery: a historical perspective
@ast
Drug discovery: a historical perspective
@en
Drug discovery: a historical perspective
@nl
P3181
P1433
P1476
Drug discovery: a historical perspective
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.287.5460.1960
P407
P577
2000-03-17T00:00:00Z