Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration
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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activationAdaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cellsAngiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endotheliumDok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domainA unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and functionMolecular biology of breast cancer metastasis. Molecular expression of vascular markers by aggressive breast cancer cells.Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsSignaling pathways in the development of infantile hemangiomaVascular dysfunction as a target for adjuvant therapy in cerebral malariaStructural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificityGrb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferationAssociation of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partnerThe Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functionsDok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganizationNERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxiaRescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival functionPI3K/PTEN signaling in angiogenesis and tumorigenesisA pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitroThe PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signalingCommon and specific effects of TIE2 mutations causing venous malformationsGene expression analysis of Tek/Tie2 signaling.Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7.Specificity and affinity motifs for Grb2 SH2-ligand interactionsCoamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma.Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2.Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach.Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.Molecular control of angiopoietin signalling.The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner.Primary monocytes regulate endothelial cell survival through secretion of angiopoietin-1 and activation of endothelial Tie2Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease.Taurine prevents high glucose-induced angiopoietin-2/tie-2 system alterations and apoptosis in retinal microvascular pericytes.Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease.A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cellsIncreased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells.Claudin-4 is required for vasculogenic mimicry formation in human breast cancer cells.
P2860
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P2860
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification of Tek/Tie2 bin ...... es cell survival and migration
@ast
Identification of Tek/Tie2 bin ...... es cell survival and migration
@en
Identification of Tek/Tie2 bin ...... es cell survival and migration
@nl
type
label
Identification of Tek/Tie2 bin ...... es cell survival and migration
@ast
Identification of Tek/Tie2 bin ...... es cell survival and migration
@en
Identification of Tek/Tie2 bin ...... es cell survival and migration
@nl
prefLabel
Identification of Tek/Tie2 bin ...... es cell survival and migration
@ast
Identification of Tek/Tie2 bin ...... es cell survival and migration
@en
Identification of Tek/Tie2 bin ...... es cell survival and migration
@nl
P2093
P50
P921
P356
P1476
Identification of Tek/Tie2 bin ...... es cell survival and migration
@en
P2093
P304
P356
10.1074/JBC.274.43.30896
P407
P577
1999-10-22T00:00:00Z