Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat
about
The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1)Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's Disease patients: A pilot studyMED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expressionThe neurogenetics of alternative splicingNRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter regionBinding of hnRNP H and U2AF65 to respective G-codes and a poly-uridine tract collaborate in the N50-5'ss selection of the REST N exon in H69 cellsThe transcription factor REST is lost in aggressive breast cancer.Comparison of REST cistromes across human cell types reveals common and context-specific functionsTranscriptional activation of REST by Sp1 in Huntington's disease modelsREST-VP16 activates multiple neuronal differentiation genes in human NT2 cellsThe transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes.REST controls self-renewal and tumorigenic competence of human glioblastoma cells.Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer.Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness.The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.Epigenetics and epilepsy.Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathwayEpigenetics, nervous system tumors, and cancer stem cells.An expression based REST signature predicts patient survival and therapeutic response for glioblastoma multiforme.α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.Regulation of non-coding RNA networks in the nervous system--what's the REST of the story?The regulation of neuronal gene expression by alcohol.Regulation of gene expression during early neuronal differentiation: evidence for patterns conserved across neuron populations and vertebrate classes.NRSF: an angel or a devil in neurogenesis and neurological diseases.Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active Protector.DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis.TRF2-mediated stabilization of hREST4 is critical for the differentiation and maintenance of neural progenitors.Similarity in targets with REST points to neural and glioblastoma related miRNAsTAF4 controls differentiation of human neural progenitor cells through hTAF4-TAFH activity.The Importance of REST for Development and Function of Beta Cells.Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation.The emerging field of epigenetics in neurodegeneration and neuroprotection.Regulation of mGluR1 expression in human melanocytes and melanoma cells.Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer.Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation.Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma.Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene.Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene.Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target.
P2860
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P2860
Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Neuron-specific splicing of zi ...... served in human, mouse and rat
@ast
Neuron-specific splicing of zi ...... served in human, mouse and rat
@en
Neuron-specific splicing of zi ...... served in human, mouse and rat
@nl
type
label
Neuron-specific splicing of zi ...... served in human, mouse and rat
@ast
Neuron-specific splicing of zi ...... served in human, mouse and rat
@en
Neuron-specific splicing of zi ...... served in human, mouse and rat
@nl
prefLabel
Neuron-specific splicing of zi ...... served in human, mouse and rat
@ast
Neuron-specific splicing of zi ...... served in human, mouse and rat
@en
Neuron-specific splicing of zi ...... served in human, mouse and rat
@nl
P2093
P3181
P1476
Neuron-specific splicing of zi ...... served in human, mouse and rat
@en
P2093
P3181
P356
10.1016/S0169-328X(99)00196-5
P407
P577
1999-09-08T00:00:00Z